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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (03): 292-298. 上一篇    下一篇

综述与进展

β-内酰胺类抗生素酶促合成新进展

吴伟波1，王旭2，王娜1，吴起1，林贤福*,1   

  1. (1浙江大学化学系 杭州 310027)
    (2浙江工业大学化工与材料学院 杭州 310032)
  • 收稿日期:2005-01-27 修回日期:2005-08-11 发布日期:2006-02-28
  • 通讯作者: 林贤福

New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics

WU Wei-Bo1,WANG Xu2,WANG Na1,WU Qi1,LIN Xian-Fu*,1   

  1. (1 Department of Chemistry, Zhejiang University, Hangzhou 310027)
    (2 Institute of Chemical Engineering and Material Science, Zhejiang University of Technol-ogy, Hangzhou 310032)
  • Received:2005-01-27 Revised:2005-08-11 Published:2006-02-28
  • Contact: LIN Xian-Fu

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β-内酰胺类抗生素的合成在制药工业中占据重要的地位, 相关的酶促合成方法研究备受关注; 酶促合成显著提高合成效率, 减少三废的排放, 是实现绿色合成的有效方法. 综述了近年来β-内酰胺类抗生素酶促合成研究的新进展, 包括一锅合成法、原位产物排出法、介质技术和酶固定化方法.

关键词: β-内酰胺类抗生素, 绿色工艺, 青霉素, 酶促合成, 头孢菌素

Semi-synthetic β-lactam antibiotics plays a significant role in pharmaceutical industry. Enzymatic synthesis of β-lactam antibiotics provides an effective green technology, which could decline the generation of waste and the cost of production remarkably. This review focuses on the recent progresses of enzymatic semi-synthesis of β-lactam antibiotics, mainly including one-pot synthesis, in situ product removal, media techniques and immobilization techniques of enzyme.

Key words: penicillin, green technology, cephalosporin, enzymatic synthesis, β-lactam antibiotics