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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (03): 329-332. 上一篇    下一篇

研究论文

黑龙骨中两个新强心苷的结构鉴定

张援虎，陈东林，王锋鹏*   

  1. (四川大学华西药学院天然药物化学教研室 成都 610041)
  • 收稿日期:2005-05-25 修回日期:2005-09-21 发布日期:2006-02-28
  • 通讯作者: 王锋鹏

Two Novel Cardiac Glycosides from Periploca forrestii

ZHANG Yuan-Hu,CHEN Dong-Lin,WANG Feng-Peng*   

  1. (Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy,
    Sichuan University, Chengdu 610041)
  • Received:2005-05-25 Revised:2005-09-21 Published:2006-02-28
  • Contact: WANG Feng-Peng

PDF

1077

被引次数

37 | 4

系统研究黑龙骨Periploca forrestii Schltr.中的化学成分, 利用各种色谱技术进行分离, 得到2个新类型的强心苷,黑龙骨苷甲和乙. 并通过化学和光谱方法(MS, 1H, 13C NMR和2D NMR)鉴定其结构为: 5β-羟基-8,14β-环氧-强心 甾- 20(22)-烯-3-O-β-D-磁麻吡喃糖苷(1)和5β-羟基-8,14β-环氧-强心甾-20(22)-烯-3-O-β-D-葡萄吡喃糖基-(1→4)-β-D-磁麻吡喃糖苷(2).

关键词: 黑龙骨, 黑龙骨苷乙, 强心苷, 黑龙骨苷甲, 黑龙骨苷元A

Various chromatographic techniques were employed for isolation and purification of Periploca forrestii Schltr. Two new types of cardiac glycosides were obtained from this plant, and their structures were identified to be 5β-hydroxy-8,14β-epoxy-carden-20(22)-olide-3β-yl-D-cymaropynanoside (1) and 5β-hy-droxy-8,14-β-epoxy-carden-20(22)-olide-3β-yl-D-glucopynanosyl-(1→4)-β-D-cymaropynanoside (2) by spectral analysis of 1H NMR, 13C NMR, 2D NMR and MS spectra.

Key words: cardiac glycoside, periploforgeside B, periploforgenin A, periploforgeside A, Periploca forrestii