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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (06): 809-815. 上一篇    下一篇

综述与进展

电喷雾质谱法研究不对称催化反应进展

赵志雄，姚胜军，王昊阳*，郭寅龙*   

  1. 中国科学院上海有机化学研究所 上海质谱中心 上海 200032
  • 收稿日期:2009-06-30 修回日期:2009-12-18 发布日期:2010-02-23
  • 通讯作者: 王昊阳 E-mail:haoyangwang@mail.sioc.ac.cn

Progress in ESI-MS Study for the Catalytic Asymmetric Reactions

ZHAO Zhi-Xiong, YAO Sheng-Jun, WANG Hao-Yang, GUO Yin-Long   

  1. Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032
  • Received:2009-06-30 Revised:2009-12-18 Published:2010-02-23
  • Contact: WANG Hao-Yang E-mail:haoyangwang@mail.sioc.ac.cn

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总结了ESI-MS在研究不对称催化反应上的应用, 包括ESI-MS技术测定不对称催化反应产物ee值和ESI-MS技术表征不对称催化反应中的活性中间体/复合物, 并进一步讨论了以此两种ESI-MS技术为基础的不对称反应对映选择性的评估和高通量手性催化剂筛选.

关键词: 质谱法, 电喷雾离子化技术, 不对称催化反应, ee值测定, 反应活性中间体

The utility of ESI-MS for studying the enantioselectivity of catalytic asymmetric reactions by measurement of the ee value of product or the different intensity of reactive intermediates/complexes involved in the asymmetric reactions, and the further evaluating and screening chiral catalysts would be discussed in this review.

Key words: mass spectrometry, electrospray ionization method, catalytic asymmetric reaction, ee value, reactive intermediate