(甘氨酰-β-丙氨酸)(二吡啶[3,2-d:2,3-f]喹喔啉)铜(II)配合物合成、结构及其超氧化物歧化酶活性

有机化学 ›› 2011, Vol. 31 ›› Issue (07): 1081-1086. 上一篇下一篇

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(甘氨酰-β-丙氨酸)(二吡啶[3,2-d:2,3-f]喹喔啉)铜(II)配合物合成、结构及其超氧化物歧化酶活性

丁杨¹，邓剑生¹，乐学义*^,1,2

(¹华南农业大学应用化学系广州 510642)
(²华南农业大学生物材料研究所广州 510642)

收稿日期:2011-01-13 修回日期:2011-03-02 发布日期:2011-03-08
通讯作者: 乐学义 E-mail:lexy@scau.edu.cn

Synthesis, Structure and Superoxide Dismutase-Like Activity of A New (Gly-cyl-β-alanine)(dipyrido[3,2-d:2,3-f]quinoxaline) Copper(II) Complex

Ding Yang¹ Deng Jiansheng¹ Le Xueyi*^,1,2

(¹ Department of Applied Chemistry, South China Agricultural University, Guangzhou 510642)
(²Institue of Biomaterial, South China Agricultural University, Guang-zhou 510642)

Received:2011-01-13 Revised:2011-03-02 Published:2011-03-08
Contact: le xueyi E-mail:lexy@scau.edu.cn

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摘要/Abstract

合成了新的(甘氨酰-β-丙氨酸)(二吡啶[3,2-d:2,3-f]喹喔啉)铜(II)配合物: [Cu(Gly-β-Ala)(dpq)]•2H₂O [Gly-β-Ala＝甘氨酰-β-丙氨酸, dpq＝二吡啶[3,2-d:2,3-f]喹喔啉]. 通过元素分析、红外光谱、紫外-可见光谱、摩尔电导率以及Ｘ射线单晶衍射对该配合物组成及结构进行了表征．配合物晶体属三斜晶系, 空间群Pī, 晶胞参数为: a＝0.70787(3) nm, b＝0.96727(4) nm, c＝0.52436(6) nm, a＝97.016(2)°, β＝100.859(2)°, γ＝108.046(2)°, V＝0.95624(7) nm³. 应用改进的氯化硝基四氮唑蓝(NBT)光照还原法研究了配合物在水溶液中催化超氧阴离子自由基( )歧化分解超氧化物歧化酶(SOD)的活性, 用循环伏安法研究了配合物的电化学性质. 结果表明: 该配合物具有良好的超氧化物歧化酶活性, 表观催化速率常数为1.53×10⁷ L•mol^－1•s^－1).

A new complex, [Cu(Gly-β-Ala)(dpq)]•2H₂O [Gly-β-Ala＝Glycyl-β-alanine, dpq＝dipyrido [3,2-d:2,3-f]quinoxaline], has been synthesized and characterized by X-ray single crystal diffraction, elemental analysis, molar conductivity, IR and UV-Vis spectra. The complex crystallizes in triclinic space group Pī, with a＝0.70787(3) nm, b＝0.96727(4) nm, c＝0.52436(6) nm, α＝97.016(2)º, β＝100.859(2)º, γ＝108.046(2)º, V＝0.95624(7) nm³. The SOD-like activity of the complex in water solution has been measured by improved nitroblue tetrazolium (NBT)-illumination method, and the electrochemical property of the complex has been studied by cyclic voltammetry method. The results indicated that the complex possesses an excellent SOD-like activity, and the rate constant (K_Q) of the complex for catalyzing the dismutation of is 1.53×10⁷ mol^－1•L•s^－1.

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丁杨, 邓剑生, 乐学义. (甘氨酰-β-丙氨酸)(二吡啶[3,2-d:2,3-f]喹喔啉)铜(II)配合物合成、结构及其超氧化物歧化酶活性[J]. 有机化学, 2011, 31(07): 1081-1086.

DING Yang, DENG Jian-Sheng, LE Xue-Yi. Synthesis, Structure and Superoxide Dismutase-Like Activity of A New (Gly-cyl-β-alanine)(dipyrido[3,2-d:2,3-f]quinoxaline) Copper(II) Complex[J]. Chin. J. Org. Chem., 2011, 31(07): 1081-1086.

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(甘氨酰-β-丙氨酸)(二吡啶[3,2-d:2,3-f]喹喔啉)铜(II)配合物合成、结构及其超氧化物歧化酶活性

Synthesis, Structure and Superoxide Dismutase-Like Activity of A New (Gly-cyl-β-alanine)(dipyrido[3,2-d:2,3-f]quinoxaline) Copper(II) Complex

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