有机化学 ›› 2012, Vol. 32 ›› Issue (06): 1072-1076.DOI: 10.6023/cjoc1202052 上一篇    下一篇

研究论文

仲烷基卤化锌与6-氯嘌呤类化合物的Negishi 偶联反应

王东超a, 牛红英a,b, 郭海明a, 魏雪姣a, 丁瑞芳a, 渠桂荣a   

  1. a 河南师范大学化学与环境科学学院 新乡 453007;
    b 河南科技学院化学化工学院 新乡 453003
  • 收稿日期:2012-02-05 修回日期:2012-02-24 发布日期:2012-03-31
  • 通讯作者: 郭海明, 渠桂荣 E-mail:ghm@htu.cn; quguir@sina.com
  • 基金资助:
    国家自然科学基金(Nos. 20772024, 21072047, 21172059)、教育部新世纪优秀人才支持计划(No. NCET-09-0122)、河南省杰出青年基金(No.114100510012)资助项目.

Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides with 6-Chloropurines

Wang Dong-Chaoa, Niu Hong-Yinga,b, Guo Hai-Minga, Wei Xue-Jiaoa, Ding Rui-Fanga, Gui-Rong Qua   

  1. a College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007;
    b School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003
  • Received:2012-02-05 Revised:2012-02-24 Published:2012-03-31
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 20772024, 21072047, 21172059), the Program for New Century Excellent Talents in University of Ministry of Education (No. NCET-09-0122), and the Excellent Youth Foundation of Henan Scientific Committee (No. 114100510012).

在室温条件下,以邻菲罗啉作为配体,无水氯化镍催化的Negishi 偶联反应合成了一系列6 位链状仲烷基取代的嘌呤化合物。该方法反应条件温和,原料易得,产物收率高。

关键词: 嘌呤, Negishi 偶联反应, 有机卤化锌

An efficient method for the synthesis of 6-acyclic secondary alkyl purines was developed via nickel-catalyzed Negishi cross-cuplings of 6-chloropurines with acyclic secondary alkylzinc halides in the presence of phenanthroline at room temperature. The process gave good to excellent isolated yields under very mild conditions.

Key words: Purine, Negishi Cross-Coupling, Organozinc Halides