硅胶负载稀土氯化铽一步催化合成多取代的β-氨基酮类化合物

doi:10.6023/cjoc201210021

有机化学 ›› 2013, Vol. 33 ›› Issue (03): 602-606.DOI: 10.6023/cjoc201210021 上一篇下一篇

研究论文

硅胶负载稀土氯化铽一步催化合成多取代的β-氨基酮类化合物

马学林^a, 张骁勇^b, 李璇^c, 刘永明^d

内蒙古包头师范学院材料物理化学重点实验室包头 014030

收稿日期:2012-10-14 修回日期:2012-11-25 发布日期:2012-11-26
通讯作者: 马学林 E-mail:maxuelin980625@163.com
基金资助:
内蒙古教育厅基金(No. NJZY12199)、内蒙古包头师范学院青年基金(No. BSYJ2011-16)资助项目.

One Pot Synthesis of Multiaryl-Substituted β-Amino Ketone Compo- unds Catalyzed by Silica-Supported Rare Earth Terbium Chloride

Ma Xuelin^a, Zhang Xiaoyong^b, Li Xuan^c, Liu Yongming^d

Received:2012-10-14 Revised:2012-11-25 Published:2012-11-26
Supported by:
Project supported by the Inner Mongolia Ministry of Education of China (No. NJZY12199), the Youth Foundation of Normal College of Baotou (No. BSYJ2011-16).

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摘要/Abstract

以苯乙酮、芳香醛和芳香胺为原料, 以硅胶负载稀土氯化铽作为环境友好型催化剂, 在室温条件下, 一步合成31个多取代的β-氨基酮类化合物. 其中部分为新的化合物. 所有化合物结构经过¹H NMR, IR和元素分析确定. 研究结果表明, 硅胶负载稀土氯化铽作为一种新型环境友好催化剂, 催化剂自身具有负载量稳定, 活化条件简单, 催化产率高. 催化反应体系条件温和, 操作简单, 不污染环境和催化剂重复回收利用等优点.

A series of multiaryl-substituted β-amino ketone compounds were synthesized by one pot reaction using acetophenone, aromatic aldehydes and aromatic amines as starting materials and silica-supported rare earth terbium chloride as catalyst. The products were characterized by ¹H NMR, IR and elemental analysis. The results showed that the support rate of catalyst was very stable and the activation condition of the catalyst was simple. This protocol has advantages of mild condition, high yield, simple work-up, environmental friendly procedure and the catalyst being able to reuse.

Key words: silica-supported rare earth terbium chloride, β-amino ketone compounds, synthesis

引用此文

马学林, 张骁勇, 李璇, 刘永明. 硅胶负载稀土氯化铽一步催化合成多取代的β-氨基酮类化合物[J]. 有机化学, 2013, 33(03): 602-606.

Ma Xuelin, Zhang Xiaoyong, Li Xuan, Liu Yongming. One Pot Synthesis of Multiaryl-Substituted β-Amino Ketone Compo- unds Catalyzed by Silica-Supported Rare Earth Terbium Chloride[J]. Chin. J. Org. Chem., 2013, 33(03): 602-606.

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硅胶负载稀土氯化铽一步催化合成多取代的β-氨基酮类化合物

One Pot Synthesis of Multiaryl-Substituted β-Amino Ketone Compo- unds Catalyzed by Silica-Supported Rare Earth Terbium Chloride

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