有机化学 ›› 2013, Vol. 33 ›› Issue (03): 409-422.DOI: 10.6023/cjoc201211003 上一篇    下一篇

研究专题

重新挖掘和调查糠卤酸: 最近的发展和在药物研发中的应用

张霁, 张英俊   

  1. 广东东阳光药业药物研究院 东莞 523871
  • 收稿日期:2012-11-02 修回日期:2012-11-27 发布日期:2012-12-03
  • 通讯作者: 张霁 E-mail:zhangji@hecpharm.com; jizhang009@yahoo.com

Reinvestigation of Mucohalic Acids: Recent Development and Application in Drug Discovery

Zhang Ji, Zhang Yingjun   

  1. HEC Pharm Group, HEC R&D Center, Dongguan 523871
  • Received:2012-11-02 Revised:2012-11-27 Published:2012-12-03

详细论述了作者实验室对糠卤酸在有机合成和药物研发中的应用进行系统研究的亲身经历. 结合糠卤酸多官能团和多反应位点的特点, 对其多样性的合成用途进行了概括性的总结. 论述了这两个活跃分子的合成原料在制备多种不饱和γ-内酯、不饱和γ-内酰胺、4, 5-二卤哒嗪-3-酮以及其它新颖的、多官能团的分子和药物的过程.

关键词: 糠卤酸, 糠氯酸, 糠溴酸, 丁烯羟酸内酯, 不饱和γ-内酰胺, 4,5-二卤哒嗪- 3-酮

The recent synthetic development and applications of mucochloric acid, mucobromic acid and their derivatives are described, mainly focus on our work using these multiple functional molecules to access a wide variety of γ-butenolides, γ-lactams, 4,5-dihalopyridazin-3-ones and other novel, multi-functionalized building blocks and pharmaceutical products.

Key words: mucohalic acid, mucochloric acid, mucobromic acid, butenolides, γ-lactams, 4,5-dihalopyridazin-3-ones