有机化学 ›› 2013, Vol. 33 ›› Issue (06): 1333-1336.DOI: 10.6023/cjoc201305025 上一篇    下一篇

研究简报

海南暗罗根中一个新的克罗烷型二萜

李小宝, 宋小平, 陈光英, 韩长日, 陈文豪, 郑彩娟, 宋鑫明   

  1. 海南师范大学化学与化工学院 热带药用植物化学教育部重点实验室 海口 571158
  • 收稿日期:2013-05-15 修回日期:2013-05-28 发布日期:2013-06-04
  • 通讯作者: 宋小平 E-mail:sxp628@126.com
  • 基金资助:

    国家自然科学基金(Nos.81160391, 21166009, 21162009)和科技部973计划前期研究专项(No.2011CB512010)资助项目.

A New Clerodane Diterpenoid from the Roots of Polyalthia laui Merr.

Li Xiaobao, Song Xiaoping, Chen Guangying, Han Changri, Chen Wenhao, Zheng Caijuan, Song Xinming   

  1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2013-05-15 Revised:2013-05-28 Published:2013-06-04
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.81160391, 21166009 and 21162009), the 973 Research Program of the Ministry of Science and Technology of China (No.2011CB512010).

采用硅胶柱层析, 制备薄层层析等色谱方法, 从海南暗罗根中分离得到8 个二萜类化合物, 分别鉴定为polyalimide A (1), kolavenic acid (2), 2-oxo-kolavenic acid (3), 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (4),3,4-dihydroxyclerodan-13E-en-15-oic acid (5), longimide B (6), 16-oxocleroda-3,13E-dien-15-oic acid (7), solidagonal acid methyl ester (8).其中化合物1为新化合物, 化合物5首次从番荔枝科分离得到, 所有化合物首次从该植物中分离得到.化合物23对人肿瘤细胞SPCA-1, SGC-7901 和K-562显示微弱的细胞毒性.

关键词: 暗罗属, 海南暗罗, polyalmide A

Eight clerodane-type compounds were isolated from the roots of Polyalthia laui and purified by silica gel column chromatorgraphy and preparative thin layer chromatorgraphy (TLC).Their structures were elucidated as polyalimide A (1),kolavenic acid (2), 2-oxo-kolavenic acid (3), 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (4), 3,4-dihydroxyclerodan-13E-en-15-oic acid (5), longimide B (6), 16-oxocleroda-3,13E-dien-15-oic acid (7), and solidagonal acid methyl ester (8).Compound 1 was a novel compound and compound 5 was isolated from this family for the first time, and all compounds were isolated for the first time from this plant material.Compounds 2 and 3 showed weakly inhibitory activities against SPC-A-1, SGC-7901 and K-562 human tumor cells.

Key words: Polyalthia, Polyalthia laui Merr., polyalimide A