二芳基甲酮亚胺的不对称催化氢化硅烷化反应研究

doi:10.6023/cjoc201512049

有机化学 ›› 2016, Vol. 36 ›› Issue (8): 1895-1906.DOI: 10.6023/cjoc201512049 上一篇下一篇

研究论文

二芳基甲酮亚胺的不对称催化氢化硅烷化反应研究

扈晓艳^a,b, 胡方芝^a,b, 张敏敏^a,b, 廖益均^a,b, 徐小英^a, 袁伟成^a, 张晓梅^a

a 中国科学院成都有机化学研究所成都 610041;
b 中国科学院大学北京 100049

收稿日期:2015-12-30 修回日期:2016-04-02 发布日期:2016-04-07
通讯作者: 张晓梅 E-mail:xmzhang@cioc.ac.cn
基金资助:
国家自然科学基金（No. 21172217）资助项目.

Enantioselective Hydrosilylation of N-Aryl Diaryl Ketimines

Hu Xiaoyan^a,b, Hu Fangzhi^a,b, Zhang Minmin^a,b, Liao Yijun^a,b, Xu Xiaoying^a, Yuan Weicheng^a, Zhang Xiaomei^a

a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041;
b University of Chinese Academy of Sciences, Beijing, 100049

Received:2015-12-30 Revised:2016-04-02 Published:2016-04-07
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21172217).

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1. 二芳基甲酮亚胺的不对称催化氢化硅烷化反应研究.PDF(7836KB)

摘要/Abstract

发展了手性路易斯碱催化的2-位无取代基的二芳基甲酮亚胺的不对称氢化硅烷化反应，在20 mol%的最优催化剂催化下，以良好的收率（最高达97%）和中等到良好的对映选择性（最高达89%）获得了一系列手性二芳基甲胺类化合物，并通过单晶X射线衍射的方法确定了其中一个反应产物的绝对构型.

关键词: 二芳基甲胺, 二芳基甲酮亚胺, 手性路易斯碱, 氢化硅烷化

Lewis base catalyzed enantioselective hydrosilylation of non-ortho-substituted N-aryl diaryl ketimines was realized. In the presence of 20 mol% of the optimal catalyst, the reactions provided a series of (diarylmethyl)amines with high yields (up to 97%) in moderate to good enantioselectivities (up to 89% ee). The absolute configuration of one product was determined by X-ray crystallographic analysis.

Key words: diarylmethylamines, diaryl ketimines, chiral Lewis base, hydrosilylation

引用此文

扈晓艳, 胡方芝, 张敏敏, 廖益均, 徐小英, 袁伟成, 张晓梅. 二芳基甲酮亚胺的不对称催化氢化硅烷化反应研究[J]. 有机化学, 2016, 36(8): 1895-1906.

Hu Xiaoyan, Hu Fangzhi, Zhang Minmin, Liao Yijun, Xu Xiaoying, Yuan Weicheng, Zhang Xiaomei. Enantioselective Hydrosilylation of N-Aryl Diaryl Ketimines[J]. Chin. J. Org. Chem., 2016, 36(8): 1895-1906.

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二芳基甲酮亚胺的不对称催化氢化硅烷化反应研究

Enantioselective Hydrosilylation of N-Aryl Diaryl Ketimines

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