银催化9-联烯嘌呤与氟代双(苯磺酰基)甲烷的单氟甲基化反应

doi:10.6023/cjoc201711001

有机化学 ›› 2018, Vol. 38 ›› Issue (1): 112-117.DOI: 10.6023/cjoc201711001 上一篇下一篇

所属专题：庆祝吴养洁院士九十华诞专辑

研究论文

银催化9-联烯嘌呤与氟代双(苯磺酰基)甲烷的单氟甲基化反应

郭真, 谢明胜, 韩瑞杰, 渠桂荣, 郭海明

河南师范大学化学化工学院新乡 453007

收稿日期:2017-11-01 修回日期:2017-11-19 发布日期:2017-11-21
通讯作者: 渠桂荣, 郭海明 E-mail:quguir@sina.com;ghm@htu.edu.cn
基金资助:
国家自然科学基金（Nos.U1604283，21402041）、河南省科技创新杰出人才（No.164200510008）、中国博士后科学基金（No.2016M592293）、河南省高校创新团队（No.15IRTSTHN003）和高等学校学科创新引智计划（111计划，No.D17007）资助项目.

Ag-Catalyzed Monofluoromethylation of Purin-9-yl Allenes with Fluorobis(phenylsulfonyl)methane

Guo Zhen, Xie Mingsheng, Han Ruijie, Qu Guirong, Guo Haiming

School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Received:2017-11-01 Revised:2017-11-19 Published:2017-11-21
Contact: 10.6023/cjoc201711001 E-mail:quguir@sina.com;ghm@htu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. U1604283, 21402041), the Plan for Scientific Innovation Talent of Henan Province (No. 164200510008), the China Postdoctoral Science Foundation Funded Project (No. 2016M592293), the Program for Innovative Research Team in Science, Technology in University of Henan Province (No. 15IRTSTHN003) and the Program of Introducing Talents of Discipline to Universities (111 Project, No. D17007).

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1. 银催化9-联烯嘌呤与氟代双(苯磺酰基)甲烷的单氟甲基化反应.PDF(3157KB)

摘要/Abstract

以氟代双（苯磺酰基）甲烷为氟化试剂，AgF（3 mol%）为催化剂，实现了9-联烯嘌呤的单氟甲基化反应，并在不同取代基的9-联烯嘌呤底物中均表现出了较好的收率.单氟甲基化反应具有较高的化学选择性和E-选择性.同时，这种方法为合成含氟嘌呤化合物提供了一种有效的途径.

关键词: 单氟甲基化反应, 9-联烯嘌呤, 氟代双(苯磺酰基)甲烷

The monofluoromethylation of purin-9-yl allenes with fluorobis(phenylsulfonyl)methane has been achieved. With AgF (3 mol%) as the catalyst, the fluorobis(phenylsulfonyl)methylated adducts could be afforded in excellent yields. The monofluoromethylation exhibited high chemoselectivities and E-selectivies. Meanwhile, the monofluoromethylation of purin-9-yl allenes with fluorobis(phenylsulfonyl)methane provided a useful route to construct fluorinated acyclic nucleoside analogues.

Key words: monofluoromethylation, purin-9-yl allene, fluorobis(phenylsulfonyl)methane

引用此文

郭真, 谢明胜, 韩瑞杰, 渠桂荣, 郭海明. 银催化9-联烯嘌呤与氟代双(苯磺酰基)甲烷的单氟甲基化反应[J]. 有机化学, 2018, 38(1): 112-117.

Guo Zhen, Xie Mingsheng, Han Ruijie, Qu Guirong, Guo Haiming. Ag-Catalyzed Monofluoromethylation of Purin-9-yl Allenes with Fluorobis(phenylsulfonyl)methane[J]. Chin. J. Org. Chem., 2018, 38(1): 112-117.

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银催化9-联烯嘌呤与氟代双(苯磺酰基)甲烷的单氟甲基化反应

Ag-Catalyzed Monofluoromethylation of Purin-9-yl Allenes with Fluorobis(phenylsulfonyl)methane

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