有机化学 ›› 2018, Vol. 38 ›› Issue (7): 1829-1832.DOI: 10.6023/cjoc201801027 上一篇    下一篇

研究简报

南鹤虱中两个新的倍半萜类化合物

成蕾, 刘贵园, 潘胤池, 张茂生, 肖世基   

  1. 遵义医学院药学院 遵义 563006
  • 收稿日期:2018-01-19 修回日期:2018-02-26 发布日期:2018-04-04
  • 通讯作者: 肖世基 E-mail:sjxiao@zmc.edu.cn
  • 基金资助:

    国家自然科学基金(No.31560102)资助项目.

Two New Sesquterpenoids from Fructus Carotae

Cheng Lei, Liu Guiyuan, Pan Yinchi, Zhang Maosheng, Xiao Shiji   

  1. School of Pharmacy, Zunyi Medical University, Zunyi 563006
  • Received:2018-01-19 Revised:2018-02-26 Published:2018-04-04
  • Contact: 10.6023/cjoc201801027 E-mail:sjxiao@zmc.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 31560102).

从中药南鹤虱(Fructus carotae)中分离纯化得到7个倍半萜类化合物,分别鉴定为7-ethoxy-4(15)-oppositen-1β-ol(1),11-乙酰氧基-8β-当归酰氧基-15-甲氧基-4α,5α-环氧愈创木烷-3-酮(2),11-乙酰氧基-8β-丙酰氧基-4-愈创木烯-3-酮(3),1-oxo-5α,7αH-eudesma-3-en-15-al(4),1β-hydroxy-4(15),7-eudesmadiene(5),1β-hydroxy-4(15),5E,10(14)-germacra-triene(6),1β-hydroxy-4(15),5-eudesmadiene(7).其中化合物12为新的化合物,新化合物的结构进一步通过HR-ESIMS,1D NMR和2D NMR等光谱技术确定.

关键词: 伞形科, 南鹤虱, 愈创木烷型, 吉马烷型, 倍半萜类

Seven sesquterpenoids were obtained from the Chinese traditional medicine, Fructus carotae, and their structures were identified as 7-ethoxy-4(15)-oppositen-1β-ol (1), 11-acetoxy-8β-angeloyloxy-15-methoxy-4α,5α-epoxyarbutane-3-one (2), 11-acetoxy-8β-propionyl-4-guaien-3-one (3), 1-oxo-5α,7αH-eudesma-3-en-15-al (4), 1β-hydroxy-4(15),7-eudesmadiene (5), 1β-hydroxy-4(15),5E,10(14)-germacratriene (6) and 1β-hydroxy-4(15),5-eudesmadiene (7). Compounds 1 and 2 were new sesquterpenoid compounds, and their structures were determined by the analysis of HR-ESIMS, 1D NMR and 2D NMR.

Key words: apiaceae, fructus carotae, arbutane, eudesmane, sesquiterpenoids