N-苄基脱除研究进展

doi:10.6023/cjoc201901031

摘要/Abstract

N-苄基是有机胺的常用保护基团，因其脱除具有便捷、高效的特点，在有机合成特别是药物和天然产物研究中具有重要地位.近年来，大量科研工作者对N-苄基脱保护进行广泛的研究，但相关工作分散，缺乏系统性综述.因此，从还原脱苄、氧化脱苄、酸碱脱苄等几个方面，系统全面地概述了N-苄基脱除研究的进展.

关键词: 有机胺, N-苄基保护, 还原脱苄, 氧化脱苄, 酸碱脱苄

N-Benzyl is a common protecting group for organic amines, owing to its convenient and efficient removal. It plays an important role in organic synthesis, especially in the research of drugs and natural products. In recent years, a large number of researchers have conducted extensive studies on N-benzyl deprotection, but the related work is scattered and lacks systematic review. Therefore, the progress of N-benzyl removal is systematically and comprehensively summarized from the aspects of reductive, oxidative and acid-base debenzylation.

Key words: organic amine, N-benzyl protection, reductive debenzylation, oxidative debenzylation, acid-base debenzylation

引用此文

周光伟, 张莉珠, 薛亚涵, 李加荣. N-苄基脱除研究进展[J]. 有机化学, 2019, 39(9): 2428-2442.

Zhou Guangwei, Zhang Lizhu, Xue Yahan, Li Jiarong. Progress of N-Benzyl Removal[J]. Chin. J. Org. Chem., 2019, 39(9): 2428-2442.

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