有机化学 ›› 2021, Vol. 41 ›› Issue (7): 2898-2904.DOI: 10.6023/cjoc202102029 上一篇    下一篇

研究简报

毛华菊中倍半萜内酯类化学成分研究

刘文琪a, 佘嘉祎a, 杨英a, 朱世明a,b, 熊校勤a,b, 谭芬a,b, 张洪权a,b,*(), 杨新洲c,*(), 曾国平a,b,*()   

  1. a 湖北第二师范学院化学与生命科学学院 武汉 430205
    b 植物抗癌活性物质提纯与应用湖北省重点实验室 武汉 430205
    c 中南民族大学药学院 武汉 430074
  • 收稿日期:2021-02-17 修回日期:2021-03-26 发布日期:2021-04-25
  • 通讯作者: 张洪权, 杨新洲, 曾国平
  • 作者简介:
    † 共同第一作者(These authors contributed equally to this work).
  • 基金资助:
    国家自然科学基金(21602052); 国家自然科学基金(81903115); 湖北省教育厅科学技术研究(B2019178); 湖北省大学生创新创业训练计划(S202014099006)

Sesquiterpene Lactones fromDendranthema vestitum(Hemsl.) Ling

Wenqi Liua, Jiayi Shea, Ying Yanga, Shiming Zhua,b, Xiaoqin Xionga,b, Fen Tana,b, Hongquan Zhanga,b(), Xinzhou Yangc(), Guoping Zenga,b()   

  1. a Department of Chemistry and Life Science, Hubei University of Education, Wuhan 430205
    b Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients, Wuhan 430205
    c College of Pharmacy, South-Central University for Nationalities, Wuhan 430074
  • Received:2021-02-17 Revised:2021-03-26 Published:2021-04-25
  • Contact: Hongquan Zhang, Xinzhou Yang, Guoping Zeng
  • Supported by:
    National Natural Science Foundation of China(21602052); National Natural Science Foundation of China(81903115); Science Research Project of Hubei Provincial Department of Education(B2019178); Undergraduate Innovation and Entreoreneurship Training Progam of Hubei Province(S202014099006)

采用溶剂提取法, Diaion HP-20、Sephadex LH-20葡聚糖凝胶、硅胶及制备高效液相等色谱方法, 对毛华菊的化学成分进行分离纯化, 并利用现代波谱技术对已分离得到的化合物进行结构鉴定. 从毛华菊的氯仿部位分离得到4个新化合物, 其结构类型属于愈创木内酯衍生物, 分别命名为(1S,5R,6S,7S,10S)-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(1)、(1S,5R,6R,7R,8S,10S)-8-异丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(2)、(1S,5R,6R,7R,8S,10S)-8-(2'-甲基)丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(3)和(1R,5R,6R,7R,8S,10S,11S)-8-乙酰氧基-愈创木-3-烯-2-酮-12,6-内酯(4), 以及2个已知化合物matricarin (5)和11,13-dehydromatricarin (6).

关键词: 毛华菊, 倍半萜内酯, 愈创木内酯

The chemical constituents fromDendranthema vestitum(Hemsl.) Ling were isolated and purified by solvent extraction, Diaion HP-20, Sephadex LH-20, silica gel and preparative high performance liquid chromatography. Their structures were elucidated based on their spectroscopic data. Four new compounds which belong to guaianolide, named as (1S,5R,6S, 7S,10S)-2-oxo-guaia-3,11(13)-dien-12,6-olide (1), (1S,5R,6R,7R,8S,10S)-2-oxo-8-isobutyryloxy-guaia-3,11(13)-dien-12,6-oli- de (2), (1S,5R,6R,7R,8S,10S)-2-oxo-8-(2'-methyl)butyryloxy-guaia-3,11(13)-dien-12,6-olide (3) and (1R,5R,6R,7R,8S,10S, 11S)-2-oxo-8-acetoxy-guaia-3-en-12,6-olide (4) together with two known compounds matricarin (5) and 11,13-dehydromatricarin (6) were isolated from chloroform extract ofDendranthema vestitum(Hemsl.) Ling.

Key words: Dendranthema vestitum(Hemsl.) Ling, sesquiterpene lactones, guaianolide