钯催化[4+1+1]环加成反应直接合成N-取代喹唑啉-2,4(1H,3H)-二酮

doi:10.6023/cjoc202100031

有机化学 ›› 2021, Vol. 41 ›› Issue (4): 1757-1758.DOI: 10.6023/cjoc202100031 上一篇

亮点述评

钯催化[4+1+1]环加成反应直接合成N-取代喹唑啉-2,4(1H,3H)-二酮

丁永正¹, 黄汉民¹^,^*()

1 中国科学技术大学化学与材料科学学院合肥微尺度物质科学国家研究中心合肥 230026

发布日期:2021-04-29
通讯作者: 黄汉民

Palladium-Catalyzed [4+1+1] Cycloaddition for the Direct Synthesis of N-Substituted Quinazoline-2,4(1H,3H)-diones

Yongzheng Ding¹, Hanmin Huang¹^,^*()

1 Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026

Published:2021-04-29
Contact: Hanmin Huang
About author:
* Corresponding author. E-mail: hanmin@ustc.edu.cn.

文章分享

摘要/Abstract

引用此文

丁永正, 黄汉民. 钯催化[4+1+1]环加成反应直接合成N-取代喹唑啉-2,4(1H,3H)-二酮[J]. 有机化学, 2021, 41(4): 1757-1758.

Yongzheng Ding, Hanmin Huang. Palladium-Catalyzed [4+1+1] Cycloaddition for the Direct Synthesis of N-Substituted Quinazoline-2,4(1H,3H)-diones[J]. Chinese Journal of Organic Chemistry, 2021, 41(4): 1757-1758.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

分享此文

图/表 3

图式1. 钯催化[4+1+1]串联环加成一步合成N-取代喹唑啉- 2,4-(1H,3H)-二酮衍生物

Scheme1 Pd. (II)-catalyzed [4+1+1] cascade cycloaddition for the synthesis of N-substituted quinazoline-2,4-(1H,3H)-dione derivatives

图式2. 底物范围考察及合成应用

Scheme 2. Representative substrates scope and synthesis application

图式3. 控制反应

Scheme 3. Control experiments

参考文献 9

[1]	Khan, I.; Ibrar, A.; Abbas, N.; Saeed, A. Eur. J. Med. Chem. 2014, 76,193. doi: 10.1016/j.ejmech.2014.02.005 pmid: 24583357
[2]	Beutner, G.L.; Hsiao, Y.; Razler, T.; Simmons, E.M.; Wertjes, W. Org. Lett. 2017, 19,1052. pmid: 28253632
[3]	Kirincich, S.J.; Xiang, J.; Green, N.; Tam, S.; Yang, H.Y.; Shim, J.; Shen, M.W. H.; Clark, J.D.; McKew, J.C. Bioorg. Med. Chem. 2009, 17,4383. doi: 10.1016/j.bmc.2009.05.027 pmid: 19482480
[4]	Buckman, B.O.; Mohan, R. Tetrahedron Lett. 1996, 37,4439.
[5]	Fehrentz, J.A.; Winternitz, F.; Martinez, J. Tetrahedron Lett. 1996, 37,7031.
[6]	Hu, Y.; Shen, Z.; Huang, H. ACS Catal. 2016, 6,6785.
[7]	Yu, H.; Zhang, G.; Huang, H. Angew. Chem., Int. Ed. 2015, 54,10912.
[8]	Wu, X.-F.; Neumann, H.; Beller, M. Chem. Rev. 2013, 113,1. pmid: 23039127
[9]	Zhang, X.; Ding, Q.; Wang, J.; Yang, J.; Fan, X.; Zhang, G. Green Chem. 2021, 23,526.

钯催化[4+1+1]环加成反应直接合成N-取代喹唑啉-2,4(1H,3H)-二酮

Palladium-Catalyzed [4+1+1] Cycloaddition for the Direct Synthesis of N-Substituted Quinazoline-2,4(1H,3H)-diones

RichHTML

PDF

可视化

摘要/Abstract

引用此文

分享此文

图/表 3

参考文献 9

相关文章 0

编辑推荐

相关统计

本文评价