N-二氟甲基吡啶盐的去芳构化反应

亮点述评

李彦霖¹, 王细胜¹^,^*()

Yanlin Li¹, Xi-Sheng Wang¹^,^*()

1 Department of Chemistry, University of Science and Technology of China, Hefei 230026

文章分享

李彦霖, 王细胜. N-二氟甲基吡啶盐的去芳构化反应[J]. 有机化学, 2021, 41(5): 2152-2154.

Yanlin Li, Xi-Sheng Wang. Dearomatization of N-Difluoromethylpyridinium Salts[J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 2152-2154.

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图式1. 吡啶盐的亲核加成反应

Scheme 1. Nucleophilc addition to pyridinium salts

图式2. 王课题组近期的研究工作

Scheme 2. Recent research work of Wang group

表1. 代表性底物范围

Table 1. Representative substrates scope

表2. 生物活性底物范围

Table 2. Scope of bioactive substrates

图式3. 提出的反应机理

Scheme 3. Proposed mechanism

图式4. N-二氟甲基吡啶盐的氧化反应

Scheme 4. Oxidation of N-difluoromethylpyridinium salt

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