栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物

doi:10.6023/cjoc202112019

有机化学 ›› 2022, Vol. 42 ›› Issue (7): 2243-2247.DOI: 10.6023/cjoc202112019 上一篇下一篇

研究简报

栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物

刘绪, 苏盼杰, 崔文博, 张宗萍, 陈晓涵, 王儒月, 费冬青^*(), 张占欣^*()

兰州大学药学院功能有机分子化学国家重点实验室兰州 730000

收稿日期:2021-12-15 修回日期:2022-03-23 发布日期:2022-08-09
通讯作者: 费冬青, 张占欣
作者简介:
^† 共同第一作者
基金资助:
国家自然科学基金(31670350); 国家自然科学基金(31870324); 甘肃省自然科学基金(21JR7RA444); 甘肃省自然科学基金(21JR7RA477)

A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea

Xu Liu, Panjie Su, Wenbo Cui, Zongping Zhang, Xiaohan Chen, Ruyue Wang, Dongqing Fei(), Zhanxin Zhang()

School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000

Received:2021-12-15 Revised:2022-03-23 Published:2022-08-09
Contact: Dongqing Fei, Zhanxin Zhang
About author:
^† These authors contributed equally to this work.
Supported by:
National Natural Science Foundation of China(31670350); National Natural Science Foundation of China(31870324); Natural Science Foundation of Gansu Province(21JR7RA444); Natural Science Foundation of Gansu Province(21JR7RA477)

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摘要/Abstract

从栗色鼠尾草全草的乙醇提取物中分离得到一个新的吉马烷型倍半萜内酯类化合物salviatanolide A (1). 化合物1的结构通过一维/二维NMR和HRESIMS波谱分析技术得到确认. 通过X-ray单晶衍射实验还确认了化合物1的绝对构型. 利用人源化秀丽隐杆线虫的阿尔兹海默症病理模型, 筛选了化合物1的抗阿尔兹海默症活性. 生物活性结果表明, 化合物1能显著地延缓秀丽隐杆线虫麻痹表型的阿尔兹海默症症状, 提示该化合物可作为抗阿尔兹海默症的候选化合物.

关键词: 栗色鼠尾草, 吉马烷型倍半萜内酯, 抗阿尔兹海默症活性, 秀丽隐杆线虫

One new germacrane-type sesquiterpene lactone, named as salviatanolide A (1) was isolated from an ethanol extract of the whole plant of Salvia castanea. Its structure was elucidated by 1D and 2D-NMR and HRESIMS spectra, and its absolute configuration was determined by single crystal X-ray crystallography. The anti-Alzheimer’s disease (AD) activity of 1 was evaluated using humanized Caenorhabditis elegans AD pathological model. Compound 1 significantly delayed AD-like symptoms of worm paralysis phenotype, which may be potential to be served as anti-AD agent candidate.

Key words: Salvia castanea, germacrane-type sesquiterpene lactone, anti-Alzheimer’s disease activity, Caenorhabditis elegans

引用此文

刘绪, 苏盼杰, 崔文博, 张宗萍, 陈晓涵, 王儒月, 费冬青, 张占欣. 栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物[J]. 有机化学, 2022, 42(7): 2243-2247.

Xu Liu, Panjie Su, Wenbo Cui, Zongping Zhang, Xiaohan Chen, Ruyue Wang, Dongqing Fei, Zhanxin Zhang. A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea[J]. Chinese Journal of Organic Chemistry, 2022, 42(7): 2243-2247.

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图/表 5

Figure 1. Chemical structure of compound 1

Figure 2. Key 1H-1H COSY and HMBC correlations of 1

Figure 3. Key NOESY correlations of 1

Figure 4. Single-crystal X-ray ORTEP drawing of 1

Figure 5. Anti-Alzheimer’s disease (AD) activity of compound 1, positive control and control Worms were treated with 100 μmol/L compound 1, 100 μmol/L memantine was regarded as positive control, and 0.1% dimethyl sulfoxide (DMSO) was regarded as control

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栗色鼠尾草中一个新的吉马烷型倍半萜内酯类化合物

A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea

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