关于亚磺酰基砌块法合成亚砜的研究进展

doi:10.6023/cjoc202510008

综述与进展

关于亚磺酰基砌块法合成亚砜的研究进展

邹震雷^#,a,b,d, 李益凡^#,b,c, 陈晨^a, 陈王哲^b, 张为钢^*,b, 王毅^*,b,d

(^a铜陵学院电气工程学院安徽省光电子应用工程技术研究中心仿生能源实验室安徽铜陵 244000)
(^b南京大学化学化工学院配位化学国家重点实验室光刻胶材料教育部工程研究中心江苏南京 210033)
(^c宿迁学院生物与材料工程学院江苏宿迁 223800)
(^d马鞍山南大高新技术研究院安徽马鞍山 238200)

收稿日期:2025-10-14 修回日期:2025-11-19
作者简介:邹震雷，博士，2016年本科毕业于天津工业大学，2017年起进入南京大学化学化工学院有机化学专业进行硕博连读学习并于2022年6月取得理学博士学位，现于铜陵学院开展工作研究。主要研究方向为电化学合成和功能材料开发。李益凡，博士，2021年硕士毕业于南京师范大学，2021年09月起进入南京大学化学化工学院有机化学专业攻读博士学位并于2025年取得理学博士学位，现于宿迁学院开展工作研究，主要研究方向为含硫试剂及功能材料开发。陈晨，本科生，2023年09月进入铜陵学院金属材料专业学习，同年12月加入铜陵学院仿生能源实验室，参与功能材料开发。陈王哲，2021年本科毕业于南京理工大学，2021年起进入南京大学化学化工学院有机化学专业硕博连读学习，已发表SCI论文4篇，主要研究方向为电化学合成与功能材料开发。张为钢，博士，2017年硕士毕业于西北师范大学，2017年09月起进入南京大学化学化工学院有机化学专业攻读博士学位并于2020年取得理学博士学位，同年留校开展博士后研究，已发表SCI论文20篇，主要研究方向为氟化试剂开发及光化学氟化反应开发。王毅，南京大学教授、博士生导师。2014年起先后任南京大学副教授和教授。近年来致力于氟化试剂的开发及功能材料开发，发表相关成果论文50余篇，包括J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、Nat. Commun.、Science Advances、ACS Catal.等期刊，获2021年度Thieme 化学奖。目前主要研究方向为氟化试剂开发、相关光电化学反应开发。
基金资助:
国家自然基金基金(No.22071101, 22271147, 22471123, 22401144)和铜陵学院基金(Nos.2023tlxyrc15, 2024tlxykjZD008)资助项目.

Recent advances in sulfoxide synthesis via sulfinyl building blocks

Zou Zhenlei^#,a,b,d, Li Yifan^#,b,c, Chen Chen^a, Chen Wangzhe^b, Zhang Weigang^*,b, Wang Yi^*,b,d

(^aAnHui Technology Research Center of Optoelectronic Technology Appliance, Biomimetic Energy Laboratory, School of Electrical Engineering, Tongling University, Tongling, 244000)
(^bState Key Laboratory of Coordination Chemistry, Engineering Research Center of Photoresist Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210033)
(^cSchool of Biological and Materials Engineering, Suqian University, Suqian, 210033)
(^dMaanshan High-Tech Research Institute of Nanjing University, Maanshan, 238200)

Received:2025-10-14 Revised:2025-11-19
Contact: ^*E-mail: zwgqlsfxy@163.com; yiwang@nju.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.22071101, 22271147, 22471123 and 22401144), Science Foundation of Tongling University (Nos.2023tlxyrc15, 2024tlxykjZD008)

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摘要/Abstract

硫元素以其丰富的价态,使得其化合物在现代合成化学、药物研发及材料科学中扮演着关键角色。尤其是亚砜及其衍生物,因独特的理化性质与广阔的生物活性,占据了核心战略地位,推动其合成方法学已经成为近年来的研究热点。基于亚磺酰基阳离子、亚磺酰基阴离子以及亚磺酰基自由基等亚磺酰基砌块的创新合成策略助力亚砜骨架的高效构筑,使得合成效率与选择性显著提升,为获取丰富的亚砜骨架提供了强大工具。本综述将系统梳理近期突破,重点探讨新型合成策略并结合可能的机理分析,为未来研究方向提供启发。

关键词: 亚砜合成, 亚磺酰基砌块, 亚磺酰基阳离子, 亚磺酰基阴离子, 亚磺酰基自由基

The diverse oxidation states of sulfur enable unique chemical reactivity in its compounds, underpinning their essential functions in modern synthetic methodologies, pharmaceutical design, and materials science. Particularly, sulfoxide compounds and their derivatives have assumed a central strategic position due to their distinctive physicochemical properties and extensive bioactivities, making the development of their synthetic methodologies a burgeoning research focus in recent years. Innovative synthetic strategies utilizing sulfinyl cations, sulfinyl anions, and sulfinyl radicals as key sulfinyl building blocks have significantly advanced the efficient construction of sulfoxide scaffolds. These approaches have markedly enhanced synthetic efficiency and selectivity, providing a robust toolkit for accessing diverse sulfoxide frameworks. This review categorizes recent advances, discusses novel approaches, and provides mechanistic analysis to guide future research.

Key words: Sulfoxide synthesis, Sulfiny building blocks, Sulfinyl cation, Sulfinyl anion, Sulfinyl radical

引用此文

邹震雷, 李益凡, 陈晨, 陈王哲, 张为钢, 王毅. 关于亚磺酰基砌块法合成亚砜的研究进展[J]. 有机化学, doi: 10.6023/cjoc202510008.

Zou Zhenlei, Li Yifan, Chen Chen, Chen Wangzhe, Zhang Weigang, Wang Yi. Recent advances in sulfoxide synthesis via sulfinyl building blocks[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202510008.

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