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2012 , Vol. 32 >Issue 04: 651 - 660

DOI: https://doi.org/10.6023/cjoc1109192

综述与进展

4-羟基-2-吡啶酮类化合物的合成研究进展

  • 赵圣印 ,
  • 黄婧 ,
  • 程健 ,
  • 刘宝硕 ,
  • 陈晨
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  • 东华大学化学化工与生物工程学院 上海 201620

收稿日期: 2011-09-19

  修回日期: 2011-11-20

  网络出版日期: 2012-04-24

基金资助

上海市自然科学基金(No. 10ZR1400700)和国家自然科学基金(No. 21072029)资助项目.

收起

Progress in the Synthesis of 4-Hydroxy-2-pyridone Derivatives

  • Zhao Shengyin ,
  • Huang Jing ,
  • Cheng Jian ,
  • Liu Baoshuo ,
  • Chen Chen
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  • College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620

Received date: 2011-09-19

  Revised date: 2011-11-20

  Online published: 2012-04-24

Supported by

Project supported by the Shanghai Municipal Natural Science Foundation of China (No. 10ZR1400700), and the National Natural Science Foundation of China (No. 21072029).

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摘要

4-羟基-2-吡啶酮是天然生物碱结构母核, 同时也是一类重要的医药中间体, 该类衍生物具有抗真菌、抗菌和抗肿瘤等多种生物活性. 因此, 其合成得到了广泛的研究和关注. 综述了近年来4-羟基-2-吡啶酮类化合物的合成方法及其研究进展.

关键词： 4-羟基-2-吡啶酮; 合成; 研究进展

本文引用格式

赵圣印 , 黄婧 , 程健 , 刘宝硕 , 陈晨 . 4-羟基-2-吡啶酮类化合物的合成研究进展[J]. 有机化学, 2012 , 32(04) : 651 -660 . DOI: 10.6023/cjoc1109192

Abstract

4-Hydroxy-2-pyridones are embedded as common structural units of many natural products, which exhibited good or excellent biological activities such as antifungal, antibacterial, and cytototoxic activity and so on. The class of compounds has stimulated a great deal of interest on synthetic chemists due to their structural novelty, molecular diversity, and promising biological activities. In this paper, the recent progress in the synthesis of 4-hydroxy-2-pyridones has been reviewed.

Key words： 4-hydroxy-2-pyridone; synthesis; research progress

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