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2012 , Vol. 32 >Issue 05: 962 - 965

DOI: https://doi.org/10.6023/cjoc1109181

研究简报

Brönsted 酸性离子液体催化3,4-二氢嘧啶-2-酮衍生物的合成

  • 刘伟华 ,
  • 高书涛 ,
  • 冯成 ,
  • 臧晓欢 ,
  • 周欣 ,
  • 马晶军 ,
  • 王春
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  • 河北农业大学理学院 保定 071001

收稿日期: 2011-09-18

  修回日期: 2011-12-03

  网络出版日期: 2012-01-04

基金资助

河北省自然科学基金(No. B2011204051)和河北农业大学理工基金(No. LG201107)资助项目.

收起

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Brönsted Acidic Ionic Liquid

  • Liu Weihua ,
  • Gao Shutao ,
  • Feng Cheng ,
  • Zang Xiaohuan ,
  • Zhou Xin ,
  • Ma Jingjun ,
  • Wang Chun
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  • College of Science, Agricultural University of Hebei, Baoding 071001

Received date: 2011-09-18

  Revised date: 2011-12-03

  Online published: 2012-01-04

Supported by

Project supported by the Natural Science Foundation of Hebei Province (No. B2011204051) and the Science and Engineering Foundation of Agricultural University of Hebei Province (No. LG201107).

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摘要

以Brönsted 酸性离子液体3-甲基咪唑丙烷磺酸-三氟乙酸作为催化剂, 无溶剂条件下由芳香醛、乙酰乙酸乙酯和尿素合成了系列3,4-二氢嘧啶-2-酮衍生物. 沸水浴中反应30～40 min, 产物产率在81%～94%之间. 该方法具有反应时间短、收率高、催化剂可回收重复使用等优点. 产物结构经1H NMR, IR 确证.

关键词： Brönsted 酸性离子液体; 3,4-二氢嘧啶-2-酮; 合成

本文引用格式

刘伟华 , 高书涛 , 冯成 , 臧晓欢 , 周欣 , 马晶军 , 王春 . Brönsted 酸性离子液体催化3,4-二氢嘧啶-2-酮衍生物的合成[J]. 有机化学, 2012 , 32(05) : 962 -965 . DOI: 10.6023/cjoc1109181

Abstract

A series of 3,4-dihydropyrimidin-2(1H)-ones were prepared through the Biginelli condensation reactions of aromatic aldehydes, keto ester and urea catalyzed by Brönsted acidic ionic liquid 3-methyl-1-(3-sulfopropyl)-imidazolium trifluoroacetate under solvent free conditions. The method is simple, solvent free, high yields and environmental friendly. The catalyst could be recycled and reused. The reactions were carried out in boiling water bath for 30～40 min. The yields of the products were between 81%～94%. All the products have been characterized by 1H NMR and IR spectra.

Key words： Brönsted acid-based ionic liquids; 3,4-dihydropyrimidin-2(1H)-one; synthesis

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