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2012 , Vol. 32 >Issue 01: 169 - 173

DOI: https://doi.org/10.6023/cjoc1107042

研究简报

二元酸茄尼醇烷基5-氟尿嘧啶二酯衍生物的合成及其抗肿瘤活性研究

  • 肖克毅 ,
  • 戴亚 ,
  • 石万棋 ,
  • 李剑忠 ,
  • 李颖 ,
  • 尹述凡
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  • a 四川大学化学学院 成都 610046;
    b 卷烟减害降焦四川省重点实验室 川渝中烟工业公司技术中心 成都 610000;
    c 四川国康药业有限公司 成都 610041

收稿日期: 2011-07-04

  修回日期: 2011-09-05

  网络出版日期: 2011-09-20

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Synthesis and Antitumor Activities of the Diacid Solanesyl 5-Fluorouracil Esters Derivatives

  • XIAO Ke-Yi ,
  • DAI Ya ,
  • SHI Wan-Qi ,
  • LI Jian-Zhong ,
  • LI Ying ,
  • YIN Shu-Fan
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  • a School of Chemistry, Sichuan University, Chengdu 610064;
    b Harmful Components and Tar Reduction in Cigarette Sichuan Key Laboratory, Technical Research Center Chuanyu Branch of China Tobacco Corporation, Chengdu 610000;
    c Sichuan Guokang Pharmaceutical Company Limited, Chengdu 610041

Received date: 2011-07-04

  Revised date: 2011-09-05

  Online published: 2011-09-20

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摘要

以茄尼醇为原料与4 种不同的酸酐反应, 然后再与N-烷羟基-替加氟反应, 得到12 个新的目标化合物. 其结构经IR, 1H NMR, MS 确认. 初步的体外抗肿瘤实验结果表明, 目标化合物具有一定抗肿瘤活性.

关键词： 茄呢醇; 替加氟; 合成; 抗肿瘤活性

本文引用格式

肖克毅 , 戴亚 , 石万棋 , 李剑忠 , 李颖 , 尹述凡 . 二元酸茄尼醇烷基5-氟尿嘧啶二酯衍生物的合成及其抗肿瘤活性研究[J]. 有机化学, 2012 , 32(01) : 169 -173 . DOI: 10.6023/cjoc1107042

Abstract

Twelve diacid solanesyl tegafur esters were synthesized by the reaction of solanesol with four acid anhydrides and N-alkoxy-tegafur. Their chemical structures were confirmed by IR, 1H NMR and MS techniques. The preliminary bioassay results show that the target compounds possess antitumor activities to some extent.

Key words： solanesol; tegafur; synthesis; antitumor activity

参考文献

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