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2012 , Vol. 32 >Issue 05: 805 - 814

DOI: https://doi.org/10.6023/cjoc1201124

综述与进展

环糊精超分子组装体与核酸的相互作用

  • 陈湧 ,
  • 刘育
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  • 南开大学化学系, 元素有机化学国家重点实验室, 天津 300071

收稿日期: 2012-01-12

  修回日期: 2012-03-07

  网络出版日期: 2012-03-23

基金资助

973 重大研究计划(2011CB932500)和国家自然科学基金(20932004, 91027007)资助项目.

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Supramolecular Assembly of Cyclodextrins and Its Interactions with Nucleic Acid

  • CHEN Yong ,
  • LIU Yu
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  • Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received date: 2012-01-12

  Revised date: 2012-03-07

  Online published: 2012-03-23

Supported by

Project supported by the 973 Program (No. 2011CB932500) and the National Natural Science Foundation of China (Nos. 20932004, 91027007).

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摘要

环糊精是一类由6-8个D-型葡萄糖连接而成的环聚多糖分子, 目前已广泛应用于化学和生物学的许多领域. 本文综述了一些生物活性的环糊精超分子组装体, 如环糊精假聚轮烷、环糊精/金纳米粒子组装体、环糊精/富勒烯组装体、环糊精/碳纳米管组装体等的构筑及其与核酸的相互作用, 如对核酸的切割、凝聚、传递作用和对核酸酶的抑制作用等方面的研究进展.

关键词： 环糊精; 核酸; 超分子组装体

本文引用格式

陈湧 , 刘育 . 环糊精超分子组装体与核酸的相互作用[J]. 有机化学, 2012 , 32(05) : 805 -814 . DOI: 10.6023/cjoc1201124

Abstract

Cyclodextrins (CDs) are a class of cyclic oligosaccharides with six to eight D-glucose units and widely applied in many fields of chemistry and biology. This reviews deals with the representative contributions in the construction of some bioactive cyclodextrin-based supramolecular assemblies, including cyclodextrin polypseudorotaxane, cyclodextrin/gold nanoparticle assembly, cyclodextrin/fullerene assembly, cyclodextrin/carbon nanotube assembly, and their interactions with nucleic acids, including the nucleic acid cleavage, condensation, delivery and the inhibition of nucleic acid enzymes.

Key words： cyclodextrin; nucleic acid; supramolecular assembly

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