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2012 >Issue 03: 532 - 537

DOI: https://doi.org/10.6023/cjoc1108102

研究论文

碱性条件下4(3H)-喹唑啉酮的一锅合成

  • 刘长娥 ,
  • 于琪瑶 ,
  • 唐健红 ,
  • 李加荣
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  • a 北京理工大学化工与环境学院 北京 100081;
    b 北京理工大学化学学院 北京100081;
    c 华侨大学化工学院 厦门 362021

收稿日期: 2011-08-10

  修回日期: 2011-11-21

  网络出版日期: 2012-03-24

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One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition

  • Liu Change ,
  • Yu Qiyao ,
  • Tang Jianhong ,
  • Li Jiarong
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  • a School of Chemical Engineering and Environment, Beijing Institude of Technology, Beijjing 100081;
    b School of Chemistry, Beijing Institude of Technology, Beijjing 100081;
    c College of Chemical Engineering, Huaqiao University, Xiamen 362021

Received date: 2011-08-10

  Revised date: 2011-11-21

  Online published: 2012-03-24

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摘要

研究了一种碱性条件下由邻氨基芳香腈1 与醛2 一锅合成4(3H)-喹唑啉酮3 的新方法. 反应经由亲核加成、分子内的Pinner 关环、Dimroth 重排和氧化脱氢串联转化而成. 产物结构经1H NMR, 13C NMR, IR 和元素分析确证.

关键词： 一锅合成; 邻氨基芳香腈; 醛; 碱催化; 4(3H)-喹唑啉酮

本文引用格式

刘长娥 , 于琪瑶 , 唐健红 , 李加荣 . 碱性条件下4(3H)-喹唑啉酮的一锅合成[J]. 有机化学, 2012 , (03) : 532 -537 . DOI: 10.6023/cjoc1108102

Abstract

A series of 4(3H)-quinazolinones 3 were obtained from the one-pot synthesis of available substituted aromatic o-aminonitriles 1 with aldehydes 2 in the present of base. This tandem transformation was included in addition, intramolecular Pinner reaction, Dimroth rearrangement and oxidative dehydrogenation. The structures of products were characterized by 1H NMR, 13C NMR, IR spectra and elemental analysis.

Key words： one-pot synthesis; aromatic o-aminonitrile; aldehyde; base catalysis; 4(3H)-quinazolinone

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