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2012 , Vol. 32 >Issue 08: 1359 - 1367

DOI: https://doi.org/10.6023/cjoc1111293

综述与进展

手性吲哚啉衍生物合成方法的研究进展

  • 张宝乐 ,
  • 秦伟 ,
  • 段迎超 ,
  • 余斌 ,
  • 张恩 ,
  • 刘宏民
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  • a 郑州大学药学院 郑州 450001;
    b 齐齐哈尔医学院药学院 齐齐哈尔 161000

收稿日期: 2011-11-29

  修回日期: 2012-01-21

  网络出版日期: 2012-03-31

基金资助

国家自然科学基金(No. 81172937)、中国博士后科学基金(No. 20100480857)和中国博士后特别资助基金(No. 201104402)资助项目.

收起

Recent Development on the Synthetic Methods of Chiral Indoline Derivatives

  • Zhang Baole ,
  • Qin Wei ,
  • Duan Yingchao ,
  • Yu Bin ,
  • Zhang En ,
  • Liu Hongmin
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  • a School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001;
    b School of Pharmacy, Qiqihar Medical University, Qiqihaer 161000

Received date: 2011-11-29

  Revised date: 2012-01-21

  Online published: 2012-03-31

Supported by

Project supported by the National Natural Science Foundation of China (No. 81172937 ), the China Postdoctoral Science Foundation (No. 20100480857), and the Special Financial Grant from the China Postdoctoral Science Foundation (No. 201104402).

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摘要

吲哚啉衍生物广泛存在于自然界中, 因具有多种生物学活性而引起广泛关注. 近年来, 手性吲哚啉衍生物成为此领域的研究热点, 也报道了多种相应的合成方法, 主要包括动力学拆分、不对称合成、手性合成子策略等, 不对称Domino级联反应作为近年来发展较快的领域, 也引起了广泛关注, 对以上合成方法加以综述.

关键词： 吲哚啉; 不对称; 合成

本文引用格式

张宝乐 , 秦伟 , 段迎超 , 余斌 , 张恩 , 刘宏民 . 手性吲哚啉衍生物合成方法的研究进展[J]. 有机化学, 2012 , 32(08) : 1359 -1367 . DOI: 10.6023/cjoc1111293

Abstract

The indoline skeletons, widely present in alkaloids and other products with diverse biological activities, which also have been considered as privileged structures due to their widespread use as building blocks and chiral auxiliaries in asymmetric synthesis. The importance of these motifs has determined that numerous synthetic multi-step strategies have been developed. Consequently, there has been a continuing interest in the development of efficient methods to obtain enantioenriched substituted indolines. A lot of methods have been introduced, including dynamic kinetic resolution, asymmetric reactions, asymmetric domino cascade reactions and other novel reactions. These methods have been reviewed.

Key words： indoline; asymmetric; synthesis

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