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2012 , Vol. 32 >Issue 06: 1072 - 1076

DOI: https://doi.org/10.6023/cjoc1202052

研究论文

仲烷基卤化锌与6-氯嘌呤类化合物的Negishi 偶联反应

  • 王东超 ,
  • 牛红英 ,
  • 郭海明 ,
  • 魏雪姣 ,
  • 丁瑞芳 ,
  • 渠桂荣
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  • a 河南师范大学化学与环境科学学院 新乡 453007;
    b 河南科技学院化学化工学院 新乡 453003

收稿日期: 2012-02-05

  修回日期: 2012-02-24

  网络出版日期: 2012-03-31

基金资助

国家自然科学基金(Nos. 20772024, 21072047, 21172059)、教育部新世纪优秀人才支持计划(No. NCET-09-0122)、河南省杰出青年基金(No.114100510012)资助项目.

收起

Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides with 6-Chloropurines

  • Wang Dong-Chao ,
  • Niu Hong-Ying ,
  • Guo Hai-Ming ,
  • Wei Xue-Jiao ,
  • Ding Rui-Fang ,
  • Gui-Rong Qu
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  • a College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007;
    b School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003

Received date: 2012-02-05

  Revised date: 2012-02-24

  Online published: 2012-03-31

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20772024, 21072047, 21172059), the Program for New Century Excellent Talents in University of Ministry of Education (No. NCET-09-0122), and the Excellent Youth Foundation of Henan Scientific Committee (No. 114100510012).

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摘要

在室温条件下,以邻菲罗啉作为配体,无水氯化镍催化的Negishi 偶联反应合成了一系列6 位链状仲烷基取代的嘌呤化合物。该方法反应条件温和,原料易得,产物收率高。

关键词： 嘌呤; Negishi 偶联反应; 有机卤化锌

本文引用格式

王东超 , 牛红英 , 郭海明 , 魏雪姣 , 丁瑞芳 , 渠桂荣 . 仲烷基卤化锌与6-氯嘌呤类化合物的Negishi 偶联反应[J]. 有机化学, 2012 , 32(06) : 1072 -1076 . DOI: 10.6023/cjoc1202052

Abstract

An efficient method for the synthesis of 6-acyclic secondary alkyl purines was developed via nickel-catalyzed Negishi cross-cuplings of 6-chloropurines with acyclic secondary alkylzinc halides in the presence of phenanthroline at room temperature. The process gave good to excellent isolated yields under very mild conditions.

Key words： Purine; Negishi Cross-Coupling; Organozinc Halides

参考文献

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