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2012 , Vol. 32 >Issue 07: 1332 - 1335

DOI: https://doi.org/10.6023/cjoc1110131

研究简报

一锅法合成4-(5-芳基-1,3,4-噻二唑-2-氨甲基)苯酚衍生物

  • 刘汉文 ,
  • 裴文丑 ,
  • 唐子龙
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  • 理论化学与分子模拟省部共建教育部重点实验室 分子构效关系湖南省普通高等学校重点实验室 湖南科技大学 湘潭 411201

收稿日期: 2011-10-13

  修回日期: 2012-02-22

  网络出版日期: 2012-03-31

基金资助

国家自然科学基金(No. 20971041)和湖南省自然科学基金(No. 11JJ3016)资助项目.

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One Pot Synthesis of Novel 4-[(5-Aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol Derivatives

  • Liu Hanwen ,
  • Pei Wenchou ,
  • Tang Zilong
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  • Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, Hunan University of Science and Technology, Xiangtan 411201

Received date: 2011-10-13

  Revised date: 2012-02-22

  Online published: 2012-03-31

Supported by

Project supported by the National Natural Science Foundation of China (No. 20971041) and the Natural Science Foundation of Hunan Province (No. 11JJ3016).

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摘要

以2-氨基-5-芳基噻二唑衍生物和对羟基苯甲醛为原料, 经亲核加成/脱水、还原两步一锅法合成了一系列新的4-(5-芳基-1,3,4-噻二唑-2-氨甲基)苯酚衍生物, 反应具有时间短、后处理简单等优点. 采用元素分析、NMR、IR 以及质谱等多种谱学技术对产物进行了详细表征.

关键词： 一锅法; 1,3,4-噻二唑; 还原; 合成

本文引用格式

刘汉文 , 裴文丑 , 唐子龙 . 一锅法合成4-(5-芳基-1,3,4-噻二唑-2-氨甲基)苯酚衍生物[J]. 有机化学, 2012 , 32(07) : 1332 -1335 . DOI: 10.6023/cjoc1110131

Abstract

A new class of 4-[(5-Aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol compounds were synthesized via the nucleophilic addition reaction of 5-phenyl-1,3,4-thiadiazol-2-amine with 4-hydroxybenzaldehyde, dehydration and reduction of unsaturated double bond in one-pot. This procedure has the advantages of short reaction time and simple post treatment. The structures of the products were characterized thoroughly by elementary analysis, NMR, IR and MS techniques.

Key words： one-pot; 1,3,4-thiadiazole; reduction; synthesis

参考文献

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