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2012 , Vol. 32 >Issue 08: 1473 - 1478

DOI: https://doi.org/10.6023/cjoc1112241

研究论文

含三元杂环席夫碱类衍生物的合成及生物活性研究

  • 熊壮 ,
  • 李海畅 ,
  • 梁娜 ,
  • 尹娟 ,
  • 卢平 ,
  • 薛伟
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  • 贵州大学精细化工研究开发中心 教育部绿色农药与农业生物工程重点实验室 贵阳 550025

收稿日期: 2011-12-24

  修回日期: 2012-02-26

  网络出版日期: 2012-04-11

基金资助

国家自然科学基金(No. 21062005)和贵州大学研究生创新基金(No. 2011033)资助项目

收起

Synthesis and Bioactivity of Three-Ring Heterocyclic Schiff Base Derivatives

  • Xiong Zhuang ,
  • Li Haichang ,
  • Liang Na ,
  • Yin Juan ,
  • Lu Ping ,
  • Xue Wei
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  • Key Laboratory of Green Pesticide and Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025

Received date: 2011-12-24

  Revised date: 2012-02-26

  Online published: 2012-04-11

Supported by

Project supported by the National Natural Science Foundation of China (No. 21062005), and the Innovation Foundation for Postgraduate Students in Guizhou University (No. 2011033).

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摘要

设计合成了10个新型的含三元杂环席夫碱类衍生物, 所有化合物结构通过1H NMR, 13C NMR, IR和元素分析确证, 生物活性初步研究结果表明, 在50 mg/L浓度下, 目标化合物对小麦赤霉菌(G. zeae)、苹果腐烂病菌(C. mandshurica)和辣椒枯萎病菌(F. oxysporum)具有一定的抑制活性.

关键词： 三唑; 哒嗪酮; 生物活性; 合成

本文引用格式

熊壮 , 李海畅 , 梁娜 , 尹娟 , 卢平 , 薛伟 . 含三元杂环席夫碱类衍生物的合成及生物活性研究[J]. 有机化学, 2012 , 32(08) : 1473 -1478 . DOI: 10.6023/cjoc1112241

Abstract

Ten novel three-ring heterocyclic Schiff-base derivatives were designed and synthesized. Their structures of all these compounds were confirmed by 1H NMR, 13C NMR, IR spectra and elemental analysis. The preliminary result of bioassay showed that the title compounds exhibited some degree of antifungal activities on G. zeae, C. mandshurica and F. oxysporum under 50 mg/L concentration.

Key words： triazole; pyridazinone; bioactivity; synthesis

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