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2012 , Vol. 32 >Issue 06: 1060 - 1066

DOI: https://doi.org/10.6023/cjoc1201292

研究论文

1-苯基-3-甲基-5-芳氧基-1H-吡唑4-甲醛-O-((2-氯吡啶-5-基)甲基)肟的合成与生物活性

  • 戴红 ,
  • 施磊 ,
  • 张海军 ,
  • 李永强 ,
  • 方建新 ,
  • 石玉军
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  • a 南通大学化学化工学院 南通 226019;
    b 南开大学元素有机化学研究所 天津 300071

收稿日期: 2012-01-29

  修回日期: 2012-03-05

  网络出版日期: 2012-04-11

基金资助

国家自然科学基金(No. 20772068)、南通市科技计划(Nos. K2010016, AS2010005, AS2011011)和南通大学自然科学基金(Nos.09Z010, 09C001)资助项目.

收起

Synthesis and Bioactivities of Novel 1-Phenyl-3-Methyl-5-Aryloxy-1H-Pyrazole-4- Carbaldehyde-O-((2-Chloropyridin-5-yl)methyl)oximes

  • Dai Hong ,
  • Shi Lei ,
  • Zhang Hai-Jun ,
  • Li Yong-Qiang ,
  • Fang Jian-Xin ,
  • Shi Yu-Jun
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  • a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received date: 2012-01-29

  Revised date: 2012-03-05

  Online published: 2012-04-11

Supported by

Project supported by the National Natural Science Foundation of China (No. 21102077), the Science and Technology Projects Fund of Nantong City (Nos. K2010016, AS2010005, AS2011011), and the Science Foundation of Nantong University (Nos. 09Z010, 09C001).

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摘要

利用1-苯基-3-甲基-5-芳氧基吡唑4-甲醛肟与2-氯-5-氯甲基吡啶发生缩合反应, 合成了14个新型含吡啶环的吡唑肟醚衍生物. 通过1H NMR、13C NMR和元素分析对所合成的化合物进行了结构表征. 初步生物活性测试结果表明, 在试验浓度下部分化合物具有一定的杀菌和植物生长调节活性.

关键词： 取代吡啶; 吡唑肟; 合成; 生物活性

本文引用格式

戴红 , 施磊 , 张海军 , 李永强 , 方建新 , 石玉军 . 1-苯基-3-甲基-5-芳氧基-1H-吡唑4-甲醛-O-((2-氯吡啶-5-基)甲基)肟的合成与生物活性[J]. 有机化学, 2012 , 32(06) : 1060 -1066 . DOI: 10.6023/cjoc1201292

Abstract

Fourteen novel pyrazole oxime ether derivatives containing a 2-chloro-5-methyl pyridyl ring were synthesized by the reaction of 1-phenyl-3-methyl-5-aryloxy-1H-pyrazole-4-carbaldehyde oximes with 2-chloro-5-chloromethyl pyridine. The structures of all new compounds were confirmed by 1H NMR, 13C NMR spectra and elemental analysis. Preliminary bioassay results indicated that some compounds exhibited certain fungicidal and plant growth regulatory activities.

Key words： substituted pyridine; pyrazole oxime; synthesis; bioactivities

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