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2012 , Vol. 32 >Issue 04: 732 - 741

DOI: https://doi.org/10.6023/cjoc1108302

研究论文

无催化剂微波促进下C—O, C—N 和C—S 交叉偶联反应研究

  • 袁艳琴 ,
  • 郭圣荣 ,
  • 莫建军 ,
  • 钱利 ,
  • 石泽凤
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  • 丽水学院化学化工系 丽水 323000

收稿日期: 2011-08-30

  修回日期: 2011-11-03

  网络出版日期: 2012-04-24

基金资助

浙江省自然科学基金基金(No. Y407240)和丽水学院重点科研(No. KZ20H03)资助项目.

收起

Rapid and Highly Efficient Microwave-Assisted C—N, C—O and C— S Coupling Reactions without a Transition-Metal Catalyst

  • Yuan Yanqin ,
  • Guo Shengrong ,
  • Mo Jianjun ,
  • Qian Li ,
  • Shi Zefeng
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  • Department of Chemistry, Lishui University, Lishui 323000

Received date: 2011-08-30

  Revised date: 2011-11-03

  Online published: 2012-04-24

Supported by

Project supported by the Natural Science Foundation of Zhejiang Province (No. Y407240) and the Key Science Foundation of Lishui University (No. KZ20H03).

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摘要

在无金属催化剂的条件下, 利用微波加热促进C—O, C—N 和C—S 交叉偶联反应. 实验发现以DMSO 为溶剂,t-BuOK 为碱, 利用微波加热, 活化的氯代芳烃能与各类亲核试剂顺利反应, 得到中等及优良的产率.

关键词： 微波; 交叉偶联反应; 芳基醚; 芳基硫醚; N-芳基化

本文引用格式

袁艳琴 , 郭圣荣 , 莫建军 , 钱利 , 石泽凤 . 无催化剂微波促进下C—O, C—N 和C—S 交叉偶联反应研究[J]. 有机化学, 2012 , 32(04) : 732 -741 . DOI: 10.6023/cjoc1108302

Abstract

A rapid and direct coupling reactions of various N/O/S nucleophilic reagents with aryl halides have been developed in good to high yields under microwave irradiation without a transition-metal catalyst. These reactions are a particularly powerful method for the coupling of electron-withdraw aryl halides with various nucleophilic reagents. A variety of products including aryl ethers, N-arylamides, and aryl thioethers were synthesized in good to excellent yields.

Key words： microwave; cross-coupling reactions; aryl ethers; aryl thioethers; N-arylation

参考文献

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