研究简报

新型咖啡酸五环三萜酯的合成与保肝活性

  • 贾炯 ,
  • 孙学华 ,
  • 邵腾飞 ,
  • 金树根 ,
  • 高月求 ,
  • 王建武
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  • a 山东大学化学与化工学院 济南 250100;
    b 上海中医药大学附属曙光医院 上海 201210

收稿日期: 2011-08-29

  修回日期: 2011-11-03

  网络出版日期: 2012-04-24

Synthesis of Novel Caffeyl Triterpenic Esters and Their Hepatic Protective Effect

  • Jia Jiong ,
  • Sun Xuehua ,
  • Shao Tengfei ,
  • Jin Shugen ,
  • Gao Yueqiu ,
  • Wang Jianwu
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  • a School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100;
    b Shanghai Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201210

Received date: 2011-08-29

  Revised date: 2011-11-03

  Online published: 2012-04-24

摘要

以天然的咖啡酸、甘草次酸和齐墩果酸为原料, 采用侧基保护、还原、酰化与去保护等步骤, 将咖啡酰基及氢化咖啡酰基引入到甘草次酸和齐墩果酸的3-位羟基上, 以较高收率合成了4 个新的咖啡酸及氢化咖啡酸五环三萜酯类化合物, 通过IR, 1H NMR, HRMS 等方法确定了化合物的结构.

本文引用格式

贾炯 , 孙学华 , 邵腾飞 , 金树根 , 高月求 , 王建武 . 新型咖啡酸五环三萜酯的合成与保肝活性[J]. 有机化学, 2012 , 32(04) : 760 -764 . DOI: 10.6023/cjoc1108291

Abstract

Four new caffeyl triterpenic esters were synthesized from natural caffeic acid, glycyrrhetinic acid and oleanolic acid. The structures of all products were characterized by IR, 1H NMR and HRMS techniques. The activities of the compounds to protect liver was tested and compound 9c showed good hepatic protective effect.

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