研究简报

桉烷-4(15)-烯-1β,7α-二醇的不对称全合成

  • 马开庆 ,
  • 张春波 ,
  • 刘明明 ,
  • 楚勇 ,
  • 胡昌其 ,
  • 叶德泳
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  • a 复旦大学药学院药物化学教研室 上海 201203;
    b 延边大学 长白山生物资源与功能分子教育部重点实验室 延吉 133000

收稿日期: 2011-06-24

  修回日期: 2011-10-16

  网络出版日期: 2012-04-24

基金资助

国家自然科学基金(No. 30672511)和创新药物平台(No. 2009ZX09301-011)资助项目.

Asymmetric Total Synthesis of 4(15)-Eudesmene-1β,7α-diol

  • Ma Kaiqing ,
  • Zhang Chunbo ,
  • Liu Mingming ,
  • Chu Yong ,
  • Hu Changqi ,
  • Ye Deyong
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  • a Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203;
    b Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji 133000

Received date: 2011-06-24

  Revised date: 2011-10-16

  Online published: 2012-04-24

Supported by

Project supported by the National Natural Science Foundation of China (No. 30672511) and the National Drug Innovative Program (No. 2009ZX09301-011).

摘要

天然产物桉烷-4(15)-烯-1β,7α-二醇(Y019)从植物中间锦鸡儿中分离得到, 初步的药理活性研究中发现具有抗稻瘟霉活性. 我们从原料1,3-环己二酮出发以线性步骤11 步反应9.4%的总产率, 首次完成了天然产物桉烷-4(15)-烯-1β,7α-二醇的不对称全合成, 为进一步的药理活性研究奠定了基础.

本文引用格式

马开庆 , 张春波 , 刘明明 , 楚勇 , 胡昌其 , 叶德泳 . 桉烷-4(15)-烯-1β,7α-二醇的不对称全合成[J]. 有机化学, 2012 , 32(04) : 781 -785 . DOI: 10.6023/cjoc1106242

Abstract

The natural product 4(15)-eudesmene-1β,7α-diol is isolated from Caragana intermedia. In the preliminary biological test, it showed anti-pyricularia oryzae P-2b activity. In order to get enough amount to support diverse biological test, the asymmetric total synthesis of this compound was completed in 11 linear steps with 9.4% yield.

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