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2012 , Vol. 32 >Issue 08: 1533 - 1538

DOI: https://doi.org/10.6023/cjoc1202271

研究简报

Fe(III)催化的烯丙醇的Friedel-Crafts环化反应合成多取代茚

  • 张继坦 ,
  • 张金花 ,
  • 方旷 ,
  • 束官莹 ,
  • 谢美华
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  • 安徽师范大学化学与材料科学学院 芜湖 241000

收稿日期: 2012-02-27

  修回日期: 2012-04-11

  网络出版日期: 2012-04-24

基金资助

国家自然科学基金(No. 20772001)资助项目.

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Synthesis of Multisubstituted Indenes by Fe(III)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols

  • Zhang Jitan ,
  • Zhang Jinhua ,
  • Fang Kuang ,
  • Shu Guanying ,
  • Xie Meihua
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  • College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000

Received date: 2012-02-27

  Revised date: 2012-04-11

  Online published: 2012-04-24

Supported by

Project supported by the National Natural Science Foundation of China (No. 20772001).

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摘要

在FeCl3·6H2O催化下, 多取代的烯丙醇可以顺利进行分子内Friedel-Crafts环化反应, 以中等到优良的产率得到一系列多取代茚化合物, 该反应操作简单、反应条件温和. 产物结构经IR, 1H NMR, 13C NMR, HR MS及X射线单晶衍射分析确证.

关键词： 烯丙醇; FeCl3·6H2O; Friedel-Crafts环化反应; 茚

本文引用格式

张继坦 , 张金花 , 方旷 , 束官莹 , 谢美华 . Fe(III)催化的烯丙醇的Friedel-Crafts环化反应合成多取代茚[J]. 有机化学, 2012 , 32(08) : 1533 -1538 . DOI: 10.6023/cjoc1202271

Abstract

FeCl3?6H2O-catalyzed intramolecular Friedel-Crafts cyclization of multisubstituted allylic alcohols proceeded smoothly and a series of multisubstituted indenes were synthesized in moderate to high yields. The reaction has the advantages of simple manipulation and mild reaction conditions. The products were characterized by IR, 1H NMR, 13C NMR, HR MS and X-ray diffraction analysis.

Key words： allylic alcohol; FeCl3?6H2O; Friedel-Crafts cyclization; indene

参考文献

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