研究论文

N-芳亚甲基-4-(4-甲氧基苯基)-5-(1H-1,2,4-三唑-1-基)-1,3-噻唑-2-胺的合成与生物活性

  • 戴红 ,
  • 周欣 ,
  • 邵玲 ,
  • 刘建兵 ,
  • 秦雪 ,
  • 方建新
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  • a 南开大学元素有机化学国家重点实验室 天津 300071;
    b 南通大学化学化工学院 南通 226019

收稿日期: 2012-02-24

  修回日期: 2012-05-11

  网络出版日期: 2012-03-30

基金资助

国家自然科学基金(No.20772068)、南通市科技计划(Nos.AS2010005, AS2011011)资助项目

Synthesis and Biological Activity of N-Substituted Benzylidene-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-amine

  • Dai Hong ,
  • Zhou Xin ,
  • Shao Ling ,
  • Liu Jianbing ,
  • Qin Xue ,
  • Fang Jianxin
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  • a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received date: 2012-02-24

  Revised date: 2012-05-11

  Online published: 2012-03-30

Supported by

Project supported by the National Natural Science Foundation of China (No.20772068), the Science and Technology Projects Fund of Nantong City (Nos.AS2010005, AS2011011)

摘要

通过2-氨基-4-(4-甲氧基苯基)-5-(1H-1,2,4-三唑-1-基)-1,3-噻唑与取代苯甲醛发生缩合,合成了一系列新型含三唑环的噻唑席夫碱类化合物.利用1H NMR和元素分析对所有化合物进行了结构表征.初步的毒性试验表明,部分标题化合物具有一定的抗肿瘤活性.

本文引用格式

戴红 , 周欣 , 邵玲 , 刘建兵 , 秦雪 , 方建新 . N-芳亚甲基-4-(4-甲氧基苯基)-5-(1H-1,2,4-三唑-1-基)-1,3-噻唑-2-胺的合成与生物活性[J]. 有机化学, 2012 , 32(9) : 1715 -1718 . DOI: 10.6023/cjoc1202242

Abstract

Reaction of 2-amino-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazole with various substituted benzal-dehydes produced a series of novel thiazole Schiff bases containing 1H-1,2,4-triazole ring. Their structures were characterized by 1H NMR spectra and elemental analysis. The bioassay data indicated that some of the title compounds showed certain antitumor activities.

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