研究简报

1-(2-氨基-3,5-二氰基-4-芳基-4H-吡喃-6-基)愈创兰烃薁的合成

  • 王道林 ,
  • 李帝 ,
  • 曹亮
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  • 辽宁省功能化合物合成与应用重点实验室 渤海大学化学化工与食品安全学院 锦州 121003

收稿日期: 2012-01-06

  修回日期: 2012-05-18

  网络出版日期: 2012-03-01

基金资助

辽宁省科技厅(No.2011220022)资助项目

Synthesis of 1-(2-Amino-3,5-dicyano-4-aryl-4H-pyran-6-yl)guaiazulenes

  • Wang Daolin ,
  • Li ,
  • Di
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  • Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry, Chemical Engineering & Food Safety, Bohai University, Jinzhou 121003

Received date: 2012-01-06

  Revised date: 2012-05-18

  Online published: 2012-03-01

Supported by

Project supported by the Science and Technology Department of Liaoning Province (No.2011220022)

摘要

在醋酸铵作用下,通过1-氰乙酰基愈创兰烃薁、芳香醛、丙二腈的三组分反应,一锅法合成了一系列1-(2-氨基-3,5-二氰基-4-芳基-4H-吡喃-6-基)愈创兰烃薁衍生物.该反应操作简单、条件温和、收率良好.产物结构经NMR,MS,IR及元素分析等得以证实.

本文引用格式

王道林 , 李帝 , 曹亮 . 1-(2-氨基-3,5-二氰基-4-芳基-4H-吡喃-6-基)愈创兰烃薁的合成[J]. 有机化学, 2012 , 32(9) : 1741 -1745 . DOI: 10.6023/cjoc1201102

Abstract

An efficient and convenient method for the one-pot three-component synthesis of 1-(2-amino-3,5-dicyano-4-aryl-4H-pyran-6-yl)guaiazulene derivatives by the condensation of 1-cyanoacetylguaiazulene, aldehydes, and malononitrile in the presence of ammonium acetate has been described. The structures of synthesized compounds were determined by NMR, IR, MS techniques and elemental analysis. This method provides several advantages such as good yield and simple work-up procedure.

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