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2012 , Vol. 32 >Issue 9: 1746 - 1748

DOI: https://doi.org/10.6023/cjoc1201302

研究简报

微波辐射下 2-乙酰氨基噻唑衍生物的一锅法合成及生物活性研究

  • 袁明月 ,
  • 刘敏 ,
  • 张英群 ,
  • 闫红飞 ,
  • 李德富 ,
  • 张冬暖 ,
  • 刘卉闵
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  • a 河北农业大学理学院 保定 071001;
    b 河北农业大学植物保护学院 保定 071001

收稿日期: 2012-01-30

  修回日期: 2012-05-18

  网络出版日期: 2012-04-24

基金资助

河北省教育厅计划(No.2009435)和河北农业大学非生命学科和新兴学科基金(No.2009020)资助项目

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One-Pot Synthesis and Biological Activity of 2-Acetamide-thiazole Derivatives under Microwave Irradiation

  • Yuan Mingyue ,
  • Liu Min ,
  • Zhang Yingqun ,
  • Yan Hongfei ,
  • Li Defu ,
  • Zhang Dongnuan ,
  • Liu Huimin
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  • a College of Science, Agricultural University of Hebei, Baoding 071001;
    b College of Plant Protection, Agricultural University of Hebei, Baoding 071001

Received date: 2012-01-30

  Revised date: 2012-05-18

  Online published: 2012-04-24

Supported by

Project supported by the Foundation of Hebei Educational Committee (No.2009435) and the Non-life Disciplines and Emerging Disciplines Foundation of Hebei Agricultural University (No.2009020)

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摘要

以α-溴代酮、硫脲和乙酸酐为原料,微波辐射下一锅法合成了8种2-乙酰氨基噻唑衍生物.该方法反应时间短、操作简单、后处理方便.目标化合物的结构通过1H NMR,IR和元素分析进行了表征.实验证明部分目标化合物具有良好的抑菌活性.

关键词： 微波; 一锅法合成; 2-乙酰氨基噻唑衍生物; 抑菌活性

本文引用格式

袁明月 , 刘敏 , 张英群 , 闫红飞 , 李德富 , 张冬暖 , 刘卉闵 . 微波辐射下 2-乙酰氨基噻唑衍生物的一锅法合成及生物活性研究[J]. 有机化学, 2012 , 32(9) : 1746 -1748 . DOI: 10.6023/cjoc1201302

Abstract

An efficient one-pot method is used to prepare a series of 2-acetamide-thiazole derivatives from α-bromoketone, thiourea and acetic anhydride under microwave irradiation. The reaction procedures have the advantages of easy work up, short time and simple operation. The products were identified by 1H NMR and IR spectra and elemental analysis. These compounds exhibit good antimicrobial activities.

Key words： microwave irradiation; one-pot synthesis; 2-acetamide-thiazole derivatives; biological activity

参考文献

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