研究论文

新型含 2-取代-1,3-噻唑烷的查尔酮类化合物的合成及其生物活性

  • 戴红 ,
  • 苗文科 ,
  • 刘建兵 ,
  • 吴珊珊 ,
  • 秦雪 ,
  • 方建新
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  • a 南开大学元素有机化学国家重点实验室 天津 300071;
    b 南通大学化学化工学院 南通 226019

收稿日期: 2012-02-21

  修回日期: 2012-05-21

  网络出版日期: 2012-04-19

基金资助

国家自然科学基金(No.20772068)、南通市科技计划(Nos.AS2010005, AS2011011)资助项目

Synthesis and Biological Activity of Novel Chalcone Derivatives Containing 2-Substituted-1,3-thiazolidine Ring

  • Dai Hong ,
  • Miao Wenke ,
  • Liu Jianbing ,
  • Wu Shanshan ,
  • Qin Xue ,
  • Fang Jianxin
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  • a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received date: 2012-02-21

  Revised date: 2012-05-21

  Online published: 2012-04-19

Supported by

Project supported by the National Natural Science Foundation of China (No.20772068), the Science and Technology Project Fund of Nantong City (Nos.AS2010005, AS2011011)

摘要

为了寻找生物活性良好的查尔酮类化合物,利用2-(2-氰基亚胺基-1,3-噻唑烷-3-基)-1-苯基乙酮或3-((2-氰基亚胺基-1,3-噻唑烷-3-基)-1-苯基-1-丙酮与取代苯甲醛发生缩合,合成了14个新型含2-取代-1,3-噻唑烷的查尔酮类化合物.其结构均经1H NMR和元素分析表征.初步的生物活性测试结果表明,在试验浓度下,部分目标化合物表现出一定的杀菌活性.

本文引用格式

戴红 , 苗文科 , 刘建兵 , 吴珊珊 , 秦雪 , 方建新 . 新型含 2-取代-1,3-噻唑烷的查尔酮类化合物的合成及其生物活性[J]. 有机化学, 2012 , 32(9) : 1690 -1694 . DOI: 10.6023/cjoc1202211

Abstract

In order to find new chalcone derivatives with good biological activity, fourteen novel chalcone compounds containing 2-substituted-1,3-thiazolidine ring were synthesized by the reaction of 2-(2-cyanoimino-1,3-thiazolidine-3-yl)-1-phenylethanone or 3-(2-cyanoimino-1,3-thiazolidine-3-yl)-1-phenylprop-1-one with different substituted benzaldehydes. All the title compounds have been confirmed by 1H NMR spectra and elemental analysis. The preliminary bioassay showed that some target compounds displayed fungicidal activities to a certain extent.

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