(+)-生物素全合成研究新进展
收稿日期: 2012-03-04
修回日期: 2012-05-14
网络出版日期: 2012-05-22
基金资助
河南中医学院“博士科研基金”(No. BSJJ2010-28)资助项目.
Recent Progresses in Total Synthesis of (+)-Biotin
Received date: 2012-03-04
Revised date: 2012-05-14
Online published: 2012-05-22
Supported by
Project supported by the Doctoral Scientific Foundation of Henan University of Traditional Chinese Medicine (No. BSJJ2010-28).
钟铮 , 武雪芬 , 陈芬儿 . (+)-生物素全合成研究新进展[J]. 有机化学, 2012 , 32(10) : 1792 -1802 . DOI: 10.6023/cjoc1203041
(+)-Biotin is one of the B vitamins. The study on total synthesis of (+)-biotin is an incessant pursuit since it was discovered half century ago. During the past ten years great advances in this field have been made. The synthetic approaches toward the target molecule can be classified into two series: the enatioselective syntheses and the stereospecific syntheses. In former approach, modification of the already existed Hoffmann-La-Roche’s lactone-thiolactone approach was further developed in diversified ways, especially the great advance in asymmetric synthesis of the chiral framework of (+)-biotin, which had been put into industrial practice successfully; in terms of the latter approach, L-cysteine or cystine can be regarded as more logical starting materials. Enriched by a plenty of ingenious novel strategies and tactics, this approach evolved more facile and practical than before.
Key words： (+)-biotin; total synthesis; progress
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