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2012 , Vol. 32 >Issue 9: 1678 - 1683

DOI: https://doi.org/10.6023/cjoc1203091

研究论文

9-乙酰氧基乙基-6-烷氨基-2-烷硫基嘌呤的合成及抗血小板凝集活性评估

  • 何琦文 ,
  • 杜洪光
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  • 北京化工大学理学院 北京 100029

收稿日期: 2012-03-09

  修回日期: 2012-05-22

  网络出版日期: 2012-04-22

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Synthesis of 9-Acetoxyethyl-6-alkylamino-2-alkylthio Purines and Their Anti-platelet Aggregation Activity

  • He Qiwen ,
  • Du Hongguang
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  • College of Science, Beijing University of Chemical Technology, Beijing 100029

Received date: 2012-03-09

  Revised date: 2012-05-22

  Online published: 2012-04-22

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摘要

以2-氨基-6-氯嘌呤(1)为原料,与2-溴乙基乙酸酯反应得到9-乙酰氧基乙基-2-氨基-6-氯嘌呤(2);2经重氮-烷硫化得到9-乙酰氧基乙基-2-烷硫基-6-氯嘌呤(3);3经胺解反应得到14个未见报道的9-乙酰氧基乙基-6-烷氨基-2-烷硫基嘌呤化合物4.这些化合物的结构经IR,1H NMR,13C NMR及HRMS得到表征,同时进行了抗血小板凝集活性测试.

关键词： 6-烷胺基-2-烷硫基嘌呤; 合成; 结构表征; 抗血小板凝集

本文引用格式

何琦文 , 杜洪光 . 9-乙酰氧基乙基-6-烷氨基-2-烷硫基嘌呤的合成及抗血小板凝集活性评估[J]. 有机化学, 2012 , 32(9) : 1678 -1683 . DOI: 10.6023/cjoc1203091

Abstract

2-Amino-6-chloropurine (1) as the starting material was treated with 2-bromoethyl acetate to yield 9-acetoxy-ethyl-2-amino-6-chloropurine (2). Compound 2 was diazotized and reacted with disulfides to afford 9-acetoxyethyl-2-alkythio-6-chloropurine (3). 9-Acetoxyethyl-6-alkylamino-2-alkylthio purines (4) were acquired by aminolysis reaction of compounds 3. Their structures were determined by IR,1H NMR,13C NMR and HRMS techniques. Meanwhile, the anti-platelet aggregation rates of compounds 4 were measured.

Key words： 6-alkylamino-2-alkylthio purine; synthesis; characterization; anti-platelet aggregation

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