研究简报

钌催化芳香硝基化合物和脂肪三级胺反应一锅法合成喹啉衍生物

  • 杨辉琼 ,
  • 谌儒 ,
  • 邓国军
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  • a 湖南工程学院化学化工学院 湘潭 411104;
    b 湘潭大学化学学院 湘潭 411105

收稿日期: 2012-02-23

  修回日期: 2012-06-01

  网络出版日期: 2012-05-16

基金资助

国家自然科学基金(No.20902076)资助项目

Ruthenium-Catalyzed One-Pot Synthesis of Quinolines from Nitroarenes and Trialkylamines

  • Yang Huiqiong ,
  • Chen Ru ,
  • Deng Guojun
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  • a College of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan 411104;
    b College of Chemistry, Xiangtan University, Xiangtan 411105

Received date: 2012-02-23

  Revised date: 2012-06-01

  Online published: 2012-05-16

Supported by

Project supported by the National Natural Science Foundation of China (No.20902076)

摘要

以芳香硝基化合物和脂肪三级胺为原料,三环己基膦四氟硼酸盐为配体,在三氯化钌催化下“一锅法”合成了一系列喹啉衍生物.该法不需要添加任何额外的还原剂,原料便宜易得,操作工艺简单,产率中等.产物结构通过IR,1H NMR,13C NMR,MS以及元素分析表征.

本文引用格式

杨辉琼 , 谌儒 , 邓国军 . 钌催化芳香硝基化合物和脂肪三级胺反应一锅法合成喹啉衍生物[J]. 有机化学, 2012 , 32(9) : 1725 -1731 . DOI: 10.6023/cjoc1202231

Abstract

A series of quinolines were synthesized in moderate yields by one-pot reaction of nitroarenes and trialkylamines in the presence of a catalytic amount of ruthenium trichloride catalyst together with tricyclohexylphosphonium tetrafluoroborate ligand. This method is convenient without extra reductant, and nitroarenes are cheap and highly available. The structures of the products were characterized by IR,1H NMR,13C NMR, MS techniques and elemental analysis.

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