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2012 , Vol. 32 >Issue 9: 1732 - 1735

DOI: https://doi.org/10.6023/cjoc1202261

研究简报

微波辐射下离子液体催化一锅三组分反应合成 3-{1-[2-(4-芳基噻唑-2-基)亚肼基]乙基}香豆素

  • 张冬暖 ,
  • 李记太 ,
  • 刘卉闵 ,
  • 宋亚丽 ,
  • 张英群 ,
  • 袁明月
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  • a 河北大学化学与环境科学学院 河北省分析科学技术重点实验室 保定 071002;
    b 河北农业大学理学院 保定 071001;
    c 河北大学药学院 保定 071001

收稿日期: 2011-02-26

  修回日期: 2012-06-01

  网络出版日期: 2012-05-12

基金资助

河北省科技厅(No.11276434)和保定市科技局(No.10ZF104)资助项目

收起

Microwave-Assisted Ionic Liquid Catalyzed One-Pot Three-Component Synthesis of 3-{1-[2-(4-Arylthiazol-2-yl)-hydrazono]ethyl}-2H-chromen-2-one

  • Zhang Dongnuan ,
  • Li Jitai ,
  • Liu Huimin ,
  • Song Yali ,
  • Zhang Yingqun ,
  • Yuan Mingyue
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  • a Key Laboratory of Analyzed Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b College of Science, Agricultural University of Hebei, Baoding 071001;
    c College of Pharmaceutical Sciences, Hebei University, Baoding 071002

Received date: 2011-02-26

  Revised date: 2012-06-01

  Online published: 2012-05-12

Supported by

Project supported by the Science and Technology Department of Hebei Province (No.11276434) and the Science and Technology Bureau of Baoding City (No.10ZF104)

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摘要

在微波辐射下,以酸性离子液体甲基咪唑丙磺酸-三氟乙酸为催化剂,利用一锅法由乙酰香豆素、氨基硫脲和α-溴代芳乙酮三组分反应合成了系列3-{1-[2-(4-芳基噻唑-2-基)亚肼基]乙基}香豆素,反应时间短,操作简便,收率高(85%～95%),催化剂可回收循环使用,对环境友好.

关键词： 酸性离子液体; 3-{1-[2-(4-芳基噻唑-2-基)亚肼基]乙基}香豆素; 微波辐射; 合成

本文引用格式

张冬暖 , 李记太 , 刘卉闵 , 宋亚丽 , 张英群 , 袁明月 . 微波辐射下离子液体催化一锅三组分反应合成 3-{1-[2-(4-芳基噻唑-2-基)亚肼基]乙基}香豆素[J]. 有机化学, 2012 , 32(9) : 1732 -1735 . DOI: 10.6023/cjoc1202261

Abstract

A series of 3-{1-[2-(4-arylthiazol-2-yl)hydrazono]ethyl}-2H-chromen-2-ones were synthesized with 85%～95% yields via the one-pot three-component reactions of acetyl coumarins, thiosemicarbazide and phenacyl bromide catalyzed by acidic ionic liquid under microwave irradiation. This method provides several advantages such as high yields, easy work-up and environmental friendly, and the catalyst can be recycled.

Key words： acidic ionic liquid; 3-{1-[2-(4-arylthiazol-2-yl)hydrazono]ethyl}-2H-chromen-2-one; microwave irradiation; synthesis

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