化学与生物转化法合成帕立骨化醇
收稿日期: 2012-04-12
修回日期: 2012-06-06
网络出版日期: 2012-06-19
基金资助
四川省科技支撑基金(No. 2010SZ124)资助项目.
Novel Synthesis of Paricalcitol by Chem-biotransformation
Received date: 2012-04-12
Revised date: 2012-06-06
Online published: 2012-06-19
Supported by
Project supported by the Science and Technology Support Fundation of Sichuan Province (No. 2010SZ124).
万阳 , 文鹏 , 张攀 , 陆群 . 化学与生物转化法合成帕立骨化醇[J]. 有机化学, 2012 , 32(10) : 1988 -1992 . DOI: 10.6023/cjoc201204015
Paricalcitol (9) was obtained from Vitamin D2 via a route of the combination of seven-step organic reaction and biotransformation. The overall yield was 3.24%, which was higher than those of the reported methods. The structures of all intermediates and product were confirmed by 1H NMR, 13C NMR and MS techniques.
Key words： vitamin D2; hydroxylation; paricalcitol
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