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2012 , Vol. 32 >Issue 08: 1429 - 1433

DOI: https://doi.org/10.6023/cjoc201205018

研究论文

水相中铜催化含氮杂环化合物的N-芳基化反应（封面文章）

  • 张敬先 ,
  • 殷慧清 ,
  • 韩世清
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  • 南京工业大学生物与制药工程学院 南京 211816

收稿日期: 2012-05-16

  修回日期: 2012-06-07

  网络出版日期: 2012-06-20

基金资助

国家自然科学基金(Nos. 20942006, 21072095)资助项目.

收起

Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water

  • Zhang Jingxian ,
  • Yin Huiqing ,
  • Han Shiqing
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  • College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816

Received date: 2012-05-16

  Revised date: 2012-06-07

  Online published: 2012-06-20

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20942006, 21072095).

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摘要

在水相中建立了一种简单实用、经济环保的实现含氮杂环化合物N-芳基化反应的催化体系. 实验发现以廉价的Cu2O为催化剂, 价廉、易获得的8-羟基喹啉为配体, n-Bu4NBr为相转移催化剂, 在水相中100℃下含氮杂环化合物与卤代芳烃顺利反应生成C—N偶联产物, 得到中等及优良的产率.

关键词： 铜催化; 氮杂环化合物; N-芳基化; 水相

本文引用格式

张敬先 , 殷慧清 , 韩世清 . 水相中铜催化含氮杂环化合物的N-芳基化反应（封面文章）[J]. 有机化学, 2012 , 32(08) : 1429 -1433 . DOI: 10.6023/cjoc201205018

Abstract

A simple, efficient, inexpensive and powerful method for the C—N coupling of nitrogen-containing heterocycles with aryl halides was developed by using cheap Cu2O as catalyst, inexpensive and readily available 8-hydroxyquinoline as ligand, n-Bu4NBr as phase transfer catalyst, water as solvent at 100℃. Most products were synthesized in good to excellent yields.

Key words： copper-catalyst; nitrogen-containing heterocycles; N-arylation; aqueous media

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