2-乙酰氧甲基吡咯衍生物和醇钠的醚化反应研究
收稿日期: 2012-05-05
修回日期: 2012-06-07
网络出版日期: 2012-06-21
基金资助
江西省自然科学基金(No. 2009GZH0078)资助项目.
Etherification of 2-Acetoxymethylpyrrole Derivative with Sodium Alkoxide
Received date: 2012-05-05
Revised date: 2012-06-07
Online published: 2012-06-21
Supported by
Project supported by the Natural Science Foundation of Jiangxi Province (No. 2009GZH0078).
研究了2-乙酰氧甲基吡咯衍生物和醇钠在回流条件下的醚化反应, 结果以优秀的收率生成了相应的2-烷氧甲基吡咯衍生物. 提出了一个基于氮杂富勒烯过渡态的反应机理用于解释实验结果, 提供了一种在碱性介质中制备2-烷氧甲基吡咯衍生物的新方法.
关键词： 2-乙酰氧甲基吡咯衍生物; 2-烷氧甲基吡咯衍生物; 醚化反应; 氮杂富勒烯; 醇钠
严兆华 , 余章昕 , 刘永杰 , 胡伟 . 2-乙酰氧甲基吡咯衍生物和醇钠的醚化反应研究[J]. 有机化学, 2012 , 32(10) : 1965 -1969 . DOI: 10.6023/cjoc201205005
Etherification of 2-acetoxymethylpyrrole derivative with sodium alkoxide at reflux was investigated in details resulting in the smooth formation of the corresponding 2-alkoxymethylpyrrole derivative in excellent yield. A plausible mechanism involving the formation of a highly reactive intermediate azafulvene species was proposed to explain the observed transformation. An alternate method for the preparation of 2-alkoxymethylpyrrole derivative starting from 2-acetoxymethylpyrrole derivative in alkaline media was provided.
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