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2012 , Vol. 32 >Issue 11: 2181 - 2186

DOI: https://doi.org/10.6023/cjoc201205006

研究简报

环状磷酸催化合成2-取代苯并咪唑

  • 王湘波 ,
  • 简腾跃 ,
  • 马晓伟 ,
  • 何林
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  • a 石河子大学化学化工学院 新疆兵团化工绿色过程重点实验室-省部共建国家重点实验室培育基地石河子 832000;
    b 中国科学院化学研究所 北京分子科学国家实验室 中国科学院分子识别与功能重点实验室 北京 100190

收稿日期: 2012-05-07

  修回日期: 2012-07-04

  网络出版日期: 2012-07-09

基金资助

中国科学院分子识别与功能重点实验室2009年开放基金(No. 2009LMRF002)、石河子大学团队创新(No. 2011ZRKETD-0403)资助项目.

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Synthesis of 2-Substituted Benzimidazoles Catalyzed by Cyclic Phosphoric Acid

  • Wang Xiangbo ,
  • Jian Tengyue ,
  • Ma Xiaowei ,
  • He Lin
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  • a Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000;
    b National Laboratory for Molecular Sciences, Chinese Academy of Sciences Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190

Received date: 2012-05-07

  Revised date: 2012-07-04

  Online published: 2012-07-09

Supported by

Project supported by the Key Laboratory of Molecular Recognition and Function, Chinese Academy of Sciences (No. 2009LMRF002), the Team Innovation Project of Shihezi University (No. 2011ZRKETD-0403).

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摘要

以邻苯二胺和醛为原料, 四氢呋喃为溶剂, 在环状磷酸催化下, 室温下合成了一系列2-取代苯并咪唑化合物. 考察了催化剂种类、用量和溶剂对反应的影响, 确定了最优反应条件, 提出了可能的反应机理. 该反应具有操作简单, 条件温和, 产率高及环境友好等优点.

关键词： 邻苯二胺; 醛; 环状磷酸; 苯并咪唑

本文引用格式

王湘波 , 简腾跃 , 马晓伟 , 何林 . 环状磷酸催化合成2-取代苯并咪唑[J]. 有机化学, 2012 , 32(11) : 2181 -2186 . DOI: 10.6023/cjoc201205006

Abstract

In the presence of cyclic phosphoric acid, a series of 2-substituted benzimidazoles were synthesized by the reaction of o-phenylenediamine and aldehyde in tetrahydrofuran at room temperature. The influence of different catalysts, catalyst amount and solvent were investigated, the optimal reaction conditions were obtained and a possible mechanism was proposed. The reaction has the virtue of simple operation, mild reaction condition, high yield and environment friendliness.

Key words： o-phenylenediamine; aldehyde; cyclic phosphoric acid; benzimidazole

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