Vilsmeier试剂近年来在环化反应中的应用
收稿日期: 2012-06-26
修回日期: 2012-08-13
网络出版日期: 2012-08-15
基金资助
国家科技重大新药创制专项(No. 2010ZX09401-404)资助项目.
Application of Vilsmeier Reagents in Cyclization in Recent Years
Received date: 2012-06-26
Revised date: 2012-08-13
Online published: 2012-08-15
Supported by
Project supported by the Significant New Drugs Creation Special Science and Technology Major of China (No. 2010ZX09401-404).
Vilsmeier-Hack反应是应用极为广泛的一类反应, Vilsmeier试剂在Vilsmeier-Hack反应中起着重要作用. Vilsmeier试剂一般是由取代酰胺和卤化物形成的复合物. 反应物在Vilsmeier试剂的作用下不仅能发生甲酰化反应, 还能发生氯化、氯化甲酰化、芳香化、重排、脱水、环化等反应, Vilsmeier试剂已经广泛地运用于有机合成的各个领域, 合成了许多在医药、农药及染料方面非常重要的化合物. 这里介绍了Vilsmeier试剂近年来在环化反应中的研究进展.
关键词： Vilsmeier-Hack反应; Vilsmeier试剂; 环化反应
钱晓庆 , 周恒 , 詹晓平 , 刘增路 , 毛振民 . Vilsmeier试剂近年来在环化反应中的应用[J]. 有机化学, 2012 , 32(12) : 2223 -2230 . DOI: 10.6023/cjoc201206026
The Vilsmeier-Hack reaction has historically been a topic of great interest to organic chemists, and it continues to attract considerable attention. The Vilsmeier-Hack reaction provides a facile entry into large numbers of aromatic and heteroaromatic systems. Vilsmeier reagents generated from amides and halides have been found to be very important in organic synthesis. Acylation, chlorination, chloroformylation, aromatization, rearrangement, dehydration and cyclization are the most reactions of Vilsmeier reagents. The application of Vilsmeier reagents in cyclization is introduced.
Key words： Vilsmeier-Hack reaction; Vilsmeier reagents; cyclization; application
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