SIOC English
有机化学
高级检索

有机化学 >

2012 , Vol. 32 >Issue 12: 2373 - 2377

DOI: https://doi.org/10.6023/cjoc201207020

研究简报

含邻氟苯基的1,2,4-三唑类衍生物的合成及杀菌活性研究

  • 童建颖 ,
  • 石延霞 ,
  • 刘幸海 ,
  • 孙娜波 ,
  • 李宝聚
展开
  • a 浙江树人大学生物与环境学院 杭州 310015;
    b 浙江工业大学化学工程与材料学院 杭州 310014;
    c 中国农业科学院蔬菜花卉研究所 北京 100014

收稿日期: 2012-07-16

  修回日期: 2012-08-10

  网络出版日期: 2012-08-15

基金资助

国家自然科学基金(No. 21002090)、浙江省重点创新团队(No. 2010R50018-06)、“十二五”国家科技支撑计划(No. 2011BAE06B03-01)资助项目.

收起

Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety

  • Tong Jianying ,
  • Shi Yanxia ,
  • Liu Xinghai ,
  • Sun Nabo ,
  • Li Baoju
Expand
  • a College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015;
    b College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014;
    c Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100014

Received date: 2012-07-16

  Revised date: 2012-08-10

  Online published: 2012-08-15

Supported by

Project supported by the National Natural Science Foundation of China (No. 21002090), the Key Innovation Team of Science and Technology in Zhejiang Province (No. 2010R50018-06), and the National Key Technologies R&D Program (No. 2011BAE06B03-01).

Fold

摘要

以邻氟苯甲酸、水合肼、苯基异硫氰酸酯等为原料, 通过多步反应制备了一系列邻氟苯基联三唑类衍生物, 并考察了微波辐射对反应的影响. 产物结构均经过1H NMR, MS和元素分析确证; 对所有化合物进行了活体杀菌活性测试, 结果表明大部分化合物对黄瓜褐斑病、黄瓜核菌病、黄瓜霜霉病、黄瓜细菌性角斑病均具有较好的防效.

关键词： 1,2,4-三唑; 合成; 杀菌活性; 邻氟苯甲酸

本文引用格式

童建颖 , 石延霞 , 刘幸海 , 孙娜波 , 李宝聚 . 含邻氟苯基的1,2,4-三唑类衍生物的合成及杀菌活性研究[J]. 有机化学, 2012 , 32(12) : 2373 -2377 . DOI: 10.6023/cjoc201207020

Abstract

A series of novel 1,2,4-triazole derivatives were synthesized from o-fluorobenzoic acid, hydrazine hydrate, phenyl isothiocyanate by multi-step reactions. Their structures were characterized by 1H NMR, MS and elemental analyses. The target compounds were evaluated for their fungicidal activities against Corynespora cassiicola, Pseudomonas syringae pv. Lachrymans, Pseudoperonospora cubensis and Sclerotinia sclerotiorum in vivo, and the results indicated that some of the title compounds displayed excellent fungicidal activities.

Key words： 1,2,4-triazole; synthesis; fungicidal activity; o-fluorobenzoic acid

参考文献

[1] Liu, X. H.; Pan, L.; Weng, J. Q.; Tan, C. X.; Li, Y.H.; Wang, B. L.; Li, Z. M. Mol. Diversity 2012, 16, 251.
[2] (a) Tan, C. X.; Shi, Y. X.; Weng, J. Q.; Liu, X. H.; Li, B. J.; Zhao, W. G. Lett. Drug Des. Discovery 2012, 9, 431.
(b) Liu, X. H.; Tan, C. X.; Weng, J. Q. Phosphorus, Sulfur Silicon Relat. Elem. 2011, 186, 558.
[3] Yin, K.; Jiang, L. H.; Zhou, H. X.; Huang, Y.; Xiang, J. N. Chin. J. Org. Chem. 2008, 28, 1016 (in Chinese).
(尹凯, 蒋历辉, 周后相, 黄勇, 向建南, 有机化学, 2008, 22, 71.)
[4] Kumar, D.; Narayanam, M. K.; Chang, K. H.; Shah, K. Chem. Biol. Drug Des. 2011, 77, 182-188.
[5] Al-Omar, M. A.; Al-Abdullah, E. S.; Shehata, I. A.; Habib, E. E.; Ibrahim, T. M.; El-Emam, A. A. Molecules 2010, 15, 2526.
[6] Kalhor, M.; Mobinikhaledi, A.; Dadras, A.; Tohidpour, M. J. Heterocycl. Chem. 2011, 48, 1366.
[7] Deng, X. Q.; Xiao, C. R.; Wei, C. X.; Quan, Z. S. Chin. J. Org. Chem. 2011, 31, 2082 (in Chinese)
(邓先清, 肖春瑞, 魏成喜, 全哲山, 有机化学, 2011, 31, 2082.)
[8] (a) Li, S.; Cui, C.; Wang, M. Y.; Yu, S. J.; Shi, Y. X.; Zhang, X.; Li, Z. M.; Zhao, W. G.; Li, B. J. J. Fluorine Chem. 2012, 137, 108.
(b) Zhou, J. K.; Song, B. A.; Xue, W.; Jin, L. H.; Gan, Z. Y. Chin. J. Org. Chem. 2011, 31, 865 (in Chinese).
(周进康, 宋宝安, 薛伟, 金林红, 干正洋, 有机化学, 2011, 31, 865.)
[9] Li, Q. Z.; Song, B. A.; Cai, X. J.; Zheng, Y. G.; Guo, Q. Q. Chin. J. Org. Chem. 2010, 30, 569 (in Chinese).
(李黔柱, 宋宝安, 蔡学建, 郑玉国, 郭晴晴, 有机化学, 2010, 30, 569.)
[10] (a) Liu, X. H.; Pan, L.; Ma, Y.; Weng, J. Q.; Tan, C. X.; Li, Y. H.; Shi, Y. X.; Li, B. J.; Li, Z. M.; Zhang, Y. G. Chem. Biol. Drug Des. 2011, 78, 689.
(b) Liu, X. H.; Weng, J. Q.; Tan, C. X. Asian J. Chem. 2011, 23, 4064.
[11] He, F. Q.; Liu, X. H.; Wang, B. L.; Li, Z. M. Heteroat. Chem. 2008, 19, 21.
[12] Guo, Y. B.; Liu, H. B.; Xu, M. Chin. J. Org. Chem. 2012, 32, 413 (in Chinese).
(郭永彪, 刘海波, 许明, 有机化学, 2012, 32, 413.)
Options
文章导航

/

〈 〉