甲亚胺叶立德的1,3-偶极环加成反应合成螺吲哚里西啶类化合物
收稿日期: 2012-07-19
修回日期: 2012-08-08
网络出版日期: 2012-08-21
基金资助
国家自然科学基金(Nos. 20971041, 21172066)资助项目.
Synthesis of Novel Spiro Indolizidine Derivatives via 1,3-Dipolar Cycloaddition of Azomethine Ylide
Received date: 2012-07-19
Revised date: 2012-08-08
Online published: 2012-08-21
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 20971041, 21172066).
李筱芳 , 易荣琼 , 刘彬 , 李志奎 , 于贤勇 , 易平贵 . 甲亚胺叶立德的1,3-偶极环加成反应合成螺吲哚里西啶类化合物[J]. 有机化学, 2012 , 32(12) : 2309 -2314 . DOI: 10.6023/cjoc201207027
The 1,3-dipolar cycloaddition of azomethine ylide generated in situ from acenaphthenequinone (isatin) and sarcosine to 7-arylmethylidene-6,7-dihydroindolizin-8(5H)-ones afforded novel 4'-aryl-1'-methyl-5'',6''-dihydro-2H,8''H- dispiro[acenaphthylene-1,2'-pyrrolidine-3',7''-indolizine]-2,8''-diones and 4'-aryl-1'-methyl-5'',6''-dihydro-8''H-dispiro[indole-3,2'-pyrrolidine-3',7''-indolizine]-2,8''(1H)-diones in moderate yields. The structures of the products were characterized thoroughly by NMR, IR, MS, elemental analysis together with X-ray crystallographic analysis.
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