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2013 , Vol. 33 >Issue 03: 483 - 491

DOI: https://doi.org/10.6023/cjoc201209034

综述与进展

抗肿瘤生物碱Lamellarin N和Lamellarin L的研究进展

  • 王爱玲 ,
  • 赵壮志 ,
  • 郑学仿 ,
  • 曹洪玉
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  • a 大连大学环境与化学工程学院 大连 116622;
    b 大连大学辽宁省生物有机化学重点实验室 大连 116622;
    c 大连大学生物工程学院 大连 116622;
    d 东北农业大学农学院 哈尔滨 150030

收稿日期: 2012-09-24

  修回日期: 2012-10-16

  网络出版日期: 2012-10-26

基金资助

国家自然科学基金(No. 20871024)、辽宁省优秀人才培养计划(No. RC-04-10)、大连市优秀青年科技人才基金(No. 2009J22DW038)资助项目.

收起

Recent Research Progress in Anticancer Alkaloid Lamellarin N and Lamellarin L

  • Wang Ailing ,
  • Zhao Zhuangzhi ,
  • Zheng Xuefang ,
  • Cao Hongyu
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  • a College of Environment and Chemical Engineering, Dalian University, Dalian 116622;
    b Liaoning Key Laboratory of Bio-organic Chemistry, Dalian University, Dalian 116622;
    c College of Bioengineering, Dalian University, Dalian 116622;
    d College of Agronomy, Northeast Agricultural University, Harbin 150030

Received date: 2012-09-24

  Revised date: 2012-10-16

  Online published: 2012-10-26

Supported by

Project supported by the National Natural Science Foundation of China (No. 20871024), the Talents Training Plan of Liaoning Province (No. RC-04-10) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).

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摘要

Lamellarins是一类从海洋无脊椎动物中分离的具有生物活性的吡咯生物碱, 其中Lamellarin N (LMN)是Lamenllarin类化合物中的一员. LMN对一系列肿瘤细胞具有很高的细胞毒性, 抑制蛋白激酶等活性, 与具有强生物活性的Lamellarin D (LMD)相比更胜一筹. 由于Lamellarin L (LML)结构和活性与LMN非常相似, 因此对其提取分离、合成、生物活性及抗肿瘤细胞机理进行了综述.

关键词： Lamellarin N; Lamellarin L; 蛋白激酶抑制剂; 细胞毒性; 化学合成

本文引用格式

王爱玲 , 赵壮志 , 郑学仿 , 曹洪玉 . 抗肿瘤生物碱Lamellarin N和Lamellarin L的研究进展[J]. 有机化学, 2013 , 33(03) : 483 -491 . DOI: 10.6023/cjoc201209034

Abstract

Lamellarins, a family of hexacyclic pyrrole alkaloids, originally isolated from marine invertebrates, display promising activities. The lamellarin N (LMN) is a member of the lamenllarin compounds. LMN exhibits a significant cytotoxicity against a large panel of cancer cell lines and potent inhibitors of various protein kinases which is better than lamellarin D (LMD). LMN and lamellarin L (LML) are similar in structure and activity. Therefore, the isolation, synthesis, biological activity and anti-cancer activity mechanism of LMN and LML are summarized.

Key words： lamellarin N; lamellarin L; protein kinases inhibitor; cytotoxic activity; chemical synthesis

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