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2013 , Vol. 33 >Issue 02: 259 - 266

DOI: https://doi.org/10.6023/cjoc201210027

综述与进展

Fusarisetin A的合成研究进展

  • 尹军 ,
  • 孔丽丽 ,
  • 高栓虎
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  • 华东师范大学化学系 上海市绿色化学与化工过程绿色化重点实验室 上海 200062

收稿日期: 2012-10-16

  修回日期: 2012-11-06

  网络出版日期: 2012-11-07

基金资助

国家自然科学基金(Nos. 21102045, 21272076);“浦江人才计划”(No. 11PJ1402800)和“新博士点教师基金”(No. 20110076120022)资助项目.

收起

Synthetic Progress of Fusarisetin A

  • Yin Jun ,
  • Kong Lili ,
  • Gao Shuanhu
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  • Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062

Received date: 2012-10-16

  Revised date: 2012-11-06

  Online published: 2012-11-07

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21102045, 21272076), the Shanghai “Pujiang Program” (No. 11PJ1402800) and the Research Fund for the Doctoral Programof Higher Education of China (No. 20110076120022).

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摘要

Fusarisetin A是一个结构新颖的tetramic acid类天然产物, 它具有6-6-5-5-5并环骨架和10个手性中心. 它对腺泡的形成以及细胞迁移和入侵有显著的抑制活性, 表明此化合物具有选择性抑制肿瘤细胞转移的潜质. 该综述总结了fusarisetin A自发现一年多时间来的合成进展情况.

关键词： fusarisetin A; 2,4-吡咯烷-二酮类天然产物; 肿瘤细胞转移; 抗肿瘤; 全合成

本文引用格式

尹军 , 孔丽丽 , 高栓虎 . Fusarisetin A的合成研究进展[J]. 有机化学, 2013 , 33(02) : 259 -266 . DOI: 10.6023/cjoc201210027

Abstract

Fusarisetin A, a new tetramic acid type natural product, contains a 6-6-5-5-5 fused pentacycles and ten stereocenters. Fusarisetin A displays significant inhibition of acinar morphogenesis as well as cell migration and invasion, and shows the potency for selective inhibition of cancer cell metastasis. This review summarizes the synthetic progress of fusarisetin A since its discovery.

Key words： fusarisetin A; tetramic acid; tumor-cell migration; antitumor; total synthesis

参考文献

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