金配合物催化的吲哚对α,β-不饱和酮的Friedel-Crafts烷基化反应
收稿日期: 2012-10-17
修回日期: 2012-11-08
网络出版日期: 2012-11-14
基金资助
国家自然科学基金(Nos. 20832001, 20972065, 21074054)资助项目.
Highly Efficient Michael-Type Friedel-Crafts Reactions Catalyzed by Gold-bipyridine Complexes
Received date: 2012-10-17
Revised date: 2012-11-08
Online published: 2012-11-14
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 20832001, 20972065, 21074054).
以金-联吡啶配合物作为催化剂高效地实现了吲哚对α,β-不饱和酮的Friedel-Crafts烷基化反应. 反应适用范围广泛, 各种取代的α,β-不饱和酮与吲哚高产率的生成相应的化合物, 底物α,β-不饱和酮分子中苯环上取代基的电负性对反应速度及产率没有明显影响. 该方法具有反应时间短、产率高、适用范围广泛、后处理方便等优点, 扩展了金催化剂在有机反应中的应用.
关键词： 金配合物; 吲哚; Friedel-Crafts反应; 不饱和酮
张艳 , 朱成建 . 金配合物催化的吲哚对α,β-不饱和酮的Friedel-Crafts烷基化反应[J]. 有机化学, 2012 , 32(12) : 2283 -2286 . DOI: 10.6023/cjoc201210030
A novel highly efficient gold-bipyridine catalyst system has been tested for Michael-type Friedel-Crafts reactions. Under the standard conditions, a series of chalcones bearing both electron-donating and electron-withdrawing substituents, reacted with indole to give the corresponding products. The protocol developed represents an efficient methodology for the Friedel-Crafts additions, which are extremely useful synthetic pathways and have widely been used in the construction of a variety of synthetically, as well as biologically important compounds.
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