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2013 , Vol. 33 >Issue 03: 648 - 651

DOI: https://doi.org/10.6023/cjoc201210014

研究简报

方便、有效地合成2-氨基-4-芳基-6-甲基四氢化萘衍生物

  • 荣良策 ,
  • 魏贤勇 ,
  • 宗志敏 ,
  • 韩笑 ,
  • 张诚义 ,
  • 沈小沣 ,
  • 陈翔
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  • a 中国矿业大学化工学院 徐州 221008;
    b 江苏师范大学化学化工学院 徐州 221116

收稿日期: 2012-10-12

  修回日期: 2012-11-21

  网络出版日期: 2012-11-26

基金资助

江苏省高校自然科学基础研究基金(No. 08KJB150017)、江苏师范大学科研平台(No. 10XLS02)和国家自然科学基金委员会创新研究群体科学基金 (No. 50921002)资助项目.

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A Facile and Efficient Synthesis of 2-Amino-6-methyl-4-aryltetrahydronaphthalene Derivatives

  • Rong Liangce ,
  • Wei Xianyong ,
  • Zong Zhimin ,
  • Han Xiao ,
  • Zhang Chengyi ,
  • Shen Xiaofeng ,
  • Chen Xiang
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  • a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received date: 2012-10-12

  Revised date: 2012-11-21

  Online published: 2012-11-26

Supported by

Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017), the Foundation of Xuzhou Normal University (No. 10XLS02), and the Foundation from National Natural Science Foundation of China for Innovative Research Group (No. 50921002).

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摘要

芳香醛、4-甲基环己酮和丙二腈在氢氧化钠存在下于95%乙醇中反应, 方便地获得一系列新的2-氨基-4-芳基-6-甲基四氢化萘衍生物. 本方法具有反应时间短、容易操作、产率高等优点. 产物的结构经过核磁、红外和高分辨质谱确定. 此方法是合成此类化合物的一条有效途径.

关键词： 四氢化萘; 4-甲基环己酮; 丙二腈; 多组分反应

本文引用格式

荣良策 , 魏贤勇 , 宗志敏 , 韩笑 , 张诚义 , 沈小沣 , 陈翔 . 方便、有效地合成2-氨基-4-芳基-6-甲基四氢化萘衍生物[J]. 有机化学, 2013 , 33(03) : 648 -651 . DOI: 10.6023/cjoc201210014

Abstract

A facile and efficient synthesis of novel 2-amino-6-methyl-4-aryltetrahydronaphthalene derivatives by the reaction of aromatic aldehydes, 4-methylcyclohexanone, and malononitrile in the presence of NaOH and 95% EtOH is reported. This protocol has the advantages of shorter reaction time, mild conditions, and easy work-up. The products were identified by 1H NMR, IR and HRMS techniques. The reported method is the efficient approach for the synthesis of these compounds.

Key words： tetrahydronaphthalene; 4-methylcyclohexanone; malononitrile; multicomponent reaction

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